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When using estrogen, whether on its own or combined with a progestin, it is important to understand the potential risks and benefits. These medications are not suitable for preventing heart disease or dementia.

• Increased Risk for Postmenopausal Women: Use of estrogen with a progestin can lead to a higher risk of heart disease, including heart attacks, stroke, serious blood clots in the lungs or legs, dementia, and cancers of the breast and ovaries.
• Consideration of Dosage and Duration: Serious side effects may vary based on the dosage and the duration of use. It is advised to use the lowest effective dose for the shortest possible time.
• Regular Medical Consultation: Regularly discuss the necessity of continuing this medication with your doctor, ideally every 3 to 6 months.
• Long-term Usage and Exams: If the medication is needed over a long period, ensure that you undergo regular comprehensive physical exams, such as annually, as suggested by your healthcare provider.

Always consult your healthcare professional to tailor the treatment to your specific needs and health status.

You might experience mild side effects such as stomach upset, nausea or vomiting, bloating, breast tenderness, headache, or changes in weight. These symptoms are usually temporary, but if they persist or worsen, it's important to consult a healthcare professional.

On some occasions, more serious side effects can occur. Be aware of persistent nausea or vomiting, mood changes like depression or memory loss, breast lumps, and unusual vaginal bleeding or irritation. Other concerning symptoms include severe abdominal pain, jaundice (yellowing of the eyes/skin), dark urine, swelling in the extremities, or increased thirst and urination. These require immediate medical attention.

In rare cases, the medication might lead to dangerous blood clots, which can result in heart attacks, strokes, or clots in the lungs or legs. Seek urgent medical help if you experience chest pain, severe headaches, sudden weakness or confusion, unexplained swelling, or difficulty breathing.

Allergic reactions to this drug are uncommon but can be serious. If you notice a rash, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing, seek emergency care promptly. Always inform your healthcare provider about any other side effects you experience.