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This document outlines crucial safety information and warnings related to the use of Bonjesta (doxylamine / pyridoxine). Please carefully consider these points and consult with your healthcare provider if you have any questions or concerns.

• Drowsiness Risk: Bonjesta can cause drowsiness. Until you discuss with your healthcare provider and understand how this medication affects you, refrain from driving, operating heavy machinery, or engaging in activities that require full attention. This precaution helps to prevent accidents, as the medication may impair your mental clarity and reaction time. Increased drowsiness may occur when combined with other sedative medications or alcohol consumption.

• Potential Worsening of Pre-existing Conditions: Bonjesta may exacerbate certain medical conditions due to its pharmacological effects and possible side effects. Conditions that may be affected include elevated eye pressure, narrow-angle glaucoma, stomach ulcers, intestinal blockages, and urinary difficulties. It is essential to inform your healthcare team of your complete medical history before initiating Bonjesta therapy to adequately weigh the benefits and risks.

• Contraindications: Do not use Bonjesta if you have allergies to doxylamine, diphenhydramine, dimenhydrinate, or pyridoxine (vitamin B6). Additionally, avoid this medication if you are currently using monoamine oxidase inhibitors (MAOIs) as it may pose significant health risks. Prior consultation with your healthcare provider is advised if any of these conditions apply to you.

When taking this medication, you might experience some common side effects such as drowsiness, dizziness, sleepiness, or blurred vision. These are generally mild, but if they persist or worsen, it is advisable to consult a healthcare professional. Other potential side effects include stomach pain, constipation, diarrhea, chest discomfort, tiredness, headache, and balance problems. These effects are often temporary and manageable, but it is important to monitor them.

In rare cases, more serious side effects can occur. These include mental or mood changes like confusion, irritability, or nervousness, as well as trouble urinating. If you experience any of these symptoms, it is crucial to seek medical advice promptly.

A very serious allergic reaction to this medication is rare but requires immediate medical attention. Symptoms of an allergic reaction can include rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing. Additionally, accidentally taking too much of this medication can lead to extreme sleepiness, dry mouth, restlessness, sensations of spinning surroundings, rapid heartbeat, and confusion, all of which require urgent care. Always be vigilant about your health and reach out to a healthcare provider if you notice any unusual symptoms.

When taking Bonjesta (doxylamine/pyridoxine), it is essential to inform your doctor and pharmacist about all other medications or supplements you are using, including prescription, over-the-counter, vitamins, and herbal products. This medication can interact with several other drugs, which can impact your treatment plan.

Avoid using Bonjesta with certain medications like Calcium Oxybate, Furazolidone, and others listed because the combination is not recommended due to potential adverse effects. Your doctor might decide against using Bonjesta or may adjust your existing medication regimen accordingly.

Additionally, Bonjesta may not be recommended for use with medications such as altretamine, acepromazine, or codeine, among others, except under specific circumstances where your doctor will need to monitor and possibly alter dosages to mitigate interaction risks.

It's important to also be cautious of products that cause drowsiness, such as opioid pain relievers, alcohol, and some antihistamines, as they might intensify certain side effects of Bonjesta. Always check medication labels for ingredients that may increase drowsiness and consult with your pharmacist for safe use.

Lastly, Bonjesta may affect the results of certain lab tests, such as urine drug screenings, potentially leading to false results. Ensure that all healthcare providers and laboratory personnel are aware that you are taking Bonjesta.