Doxylamine-pyridoxine

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doxylamine-pyridoxine

Diclegis, a combination of doxylamine and pyridoxine (vitamin B6), is prescribed to manage nausea and vomiting during pregnancy, commonly known as morning sickness. This medication is especially helpful when dietary changes or avoiding nausea triggers are insufficient. Doxylamine is an antihistamine that may work by influencing natural substances in the body or directly affecting certain brain areas, while pyridoxine is a vital B vitamin that supports overall health. Typically, treatment begins with two tablets taken orally at bedtime, with adjustments possible for greater relief. A frequent side effect is drowsiness. Both brand-name and generic versions are available. Always consult healthcare professionals for personalized advice before starting any medication.
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10-10MG, Doxylamine-pyridoxine (30 Tablet Delayed Releases)

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CVS

$32.58

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$38.24

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$55.72

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$77.76

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$169.33

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Diclegis dosage forms

The average cost for 30 Tablet Delayed Releases of Diclegis (doxylamine-pyridoxine) at 10-10MG is $32.46 with a free coupon. This is 19.43% off the average retail price of $167.1
DosageQuantityPrice fromPer unit
10-10MG30 Tablet Delayed Releases$32.46$1.08

Diclegis Warnings

The following safety and warning information is crucial for anyone considering or currently using this medication. Please read it thoroughly and consult your healthcare provider with any questions or concerns.

  • Drowsiness: Diclegis (doxylamine/pyridoxine) may cause drowsiness. To reduce the risk of accidents, refrain from driving, operating heavy machinery, or engaging in tasks that require full attention until you have discussed with your healthcare provider how this medication affects your alertness and response time. Be cautious if you are taking other drowsiness-inducing medications or consuming alcohol, as these can amplify the sedative effects.

  • Exacerbation of Other Medical Conditions: Diclegis (doxylamine/pyridoxine) may worsen certain medical conditions due to its mechanism of action and side effects. Conditions that may be affected include increased intraocular pressure, narrow-angle glaucoma, stomach ulcers, intestinal blockages, and urinary retention issues. It is vital to share your complete medical history with your healthcare team before starting this medication to assess potential risks and benefits.

  • Contraindications: This medication should not be used in the following situations due to potential serious health risks. If any of these apply to you, seek advice from your healthcare provider before use:

    • Known allergy to doxylamine, diphenhydramine, or dimenhydrinate.
    • Known allergy to pyridoxine (vitamin B6).
    • Current use of monoamine oxidase inhibitors (MAOIs).

Following these guidelines will help ensure safe use of Diclegis and mitigate potential risks. Always follow your healthcare provider's instructions and report any unusual symptoms or concerns immediately.

Diclegis Side Effects

When taking this medication, you might experience some common side effects such as drowsiness, dizziness, blurred vision, stomach upset, diarrhea, constipation, headache, and trouble sleeping. These effects are usually mild and often do not cause significant concern. However, if they persist or worsen, it is advisable to consult a healthcare professional.

In some instances, individuals may also encounter tiredness, balance problems, chest discomfort, or stomach pain. While these are not as frequent, they are generally manageable. If you find they become troublesome, reach out to your healthcare provider.

There are rare, yet serious side effects that require immediate medical attention. These include severe mental or mood changes such as confusion or irritability, trouble urinating, easy bruising or bleeding, and fast or irregular heartbeat. Additionally, if you accidentally take too much of the medication, symptoms like extreme sleepiness, dry mouth, restlessness, or a fast heart rate may occur. It is crucial to seek urgent medical care in such cases.

Although very serious allergic reactions are rare, be vigilant for symptoms like rash, severe dizziness, or difficulty breathing. Immediate medical assistance is necessary if these occur. If you notice any other unusual effects, contacting a healthcare provider is recommended.

Diclegis Interactions

When taking Diclegis (doxylamine/pyridoxine), it's important to be aware of possible drug interactions. Inform your healthcare provider about all the medications and supplements you are currently using, including prescription and over-the-counter drugs, as well as vitamins and herbal products.

Some products that can interact with Diclegis include altretamine and skin-applied antihistamines like diphenhydramine creams or ointments. Additionally, be cautious if you're using medications that cause drowsiness, such as opioid pain relievers (e.g., codeine, hydrocodone), alcohol, marijuana, sleep aids, anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem), muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine), or other antihistamines (e.g., Cetirizine, diphenhydramine).

Some medications should generally not be combined with Diclegis. These include certain MAO inhibitors and other drugs like Calcium Oxybate and Phenelzine, among others. If your doctor prescribes these along with Diclegis, they may adjust the dosage or frequency of use to manage the interaction.

Furthermore, Diclegis might affect the results of some lab tests, such as urine drug screenings, potentially leading to false results. Therefore, ensure all medical personnel involved in your care are aware that you are taking this medication. Always check with your pharmacist or doctor for guidance on the safe use of any additional products.

Diclegis FAQs
What is the controversy with Diclegis?

The controversy surrounding Diclegis primarily involves its effectiveness and marketing. Diclegis, a medication used to treat nausea and vomiting during pregnancy, was initially withdrawn from the market in the 1980s due to concerns about potential birth defects, although these concerns were later found to be unfounded. It was reintroduced in 2013, but some critics argue that its effectiveness is not significantly greater than a placebo. Additionally, there have been discussions about the high cost of Diclegis compared to its generic components, doxylamine and pyridoxine, which can be purchased separately at a lower price.

Diclegis is a medication that is commonly prescribed to treat nausea and vomiting during pregnancy, often referred to as morning sickness. It is considered safe for use during pregnancy and is classified as a Category A drug by the FDA, indicating that controlled studies in pregnant women have not shown any risk to the fetus. However, it is always important for pregnant individuals to consult with their healthcare provider before starting any medication to ensure it is appropriate for their specific situation.

Debendox, known as Bendectin in the United States, was taken off the market in the early 1980s due to concerns about its safety during pregnancy. There were allegations that the drug, used to treat nausea and vomiting in pregnant women, was linked to birth defects. Although subsequent studies did not find conclusive evidence supporting these claims, the manufacturer decided to withdraw the drug due to the high costs of litigation and declining sales.

For managing nausea during pregnancy, vitamin B6 (pyridoxine) and doxylamine are often recommended as first-line treatments. These can be taken separately or in combination, as found in some over-the-counter medications. However, it is important for the individual to consult with a healthcare provider before starting any medication to ensure it is safe and appropriate for their specific situation.

Doxylamine is an antihistamine that is sometimes used in combination with pyridoxine (vitamin B6) to treat nausea and vomiting during pregnancy. It is generally considered safe for use during pregnancy, particularly in the first trimester, and is classified as a Category A medication by the FDA, indicating no known risk to the fetus based on human studies. However, it is always important for pregnant individuals to consult with their healthcare provider before taking any medication to ensure it is appropriate for their specific situation.