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The following safety information is crucial for the proper use of Ycanth (cantharidin). Please review these warnings thoroughly and consult with your healthcare provider if you have any questions or concerns.

• Serious Toxicities: Immediate medical attention is necessary if Ycanth (cantharidin) inadvertently contacts the eyes, mouth, or nose. This medication is intended solely for external use on the skin and should be washed off 24 hours post-application. Accidental transfer to other body areas can occur if treated areas are touched and then the eyes or mouth are contacted. Risks include ingestion or contact with eyes or nose.

• Skin Reactions: Application of Ycanth (cantharidin) may lead to irritation or damage if it comes into contact with healthy skin. Possible reactions include blistering, redness, discoloration, and pain. Healthcare providers will apply the medication directly to lesions, and any accidental application to healthy skin will be promptly removed using a cotton swab. Risks involve contact with healthy skin and using other products on treated areas.

• Fire Hazard: Ycanth (cantharidin) remains flammable even after drying. It is important to steer clear of open flames, fire, or smoking near the application site until the medication is thoroughly washed off. Risks include proximity to fire or flames and smoking near treated lesions.

Please adhere to these precautions to ensure safe use of the medication.

Common side effects:

• Blistering
• Itching
• Pain
• Scabbing
• Discoloration
• Redness

Less common but important to monitor:

• Dryness
• Swelling

Serious side effects:

• Toxicity leading to kidney damage
• Seizures
• Paralysis
• Reduced urination
• Dark urine
• Difficulty breathing
• Swelling of extremities
• Red or teary eyes
• Blurred vision
• Eye pain
• Vision loss

Cantharidin is a topical medication used to treat skin conditions like molluscum contagiosum. When applied to the skin, it is minimally absorbed into the bloodstream, resulting in low systemic exposure. Consequently, the likelihood of cantharidin interacting with other medications is considered low. However, no formal studies have been conducted to evaluate potential drug interactions with cantharidin.

In animal studies, cantharidin has been shown to affect certain liver enzymes responsible for metabolizing drugs. Specifically, it inhibited the activity of enzymes CYP2D6 and CYP3A4, while inducing CYP2C9. These findings suggest that cantharidin could potentially alter the metabolism of medications processed by these enzymes. However, it's important to note that these effects were observed in rats, and their relevance to humans remains uncertain.

Given the limited data on cantharidin's interactions with other drugs, it's advisable to inform your healthcare provider about all medications, supplements, and over-the-counter products you are currently using before starting treatment with cantharidin. This precaution helps ensure safe and effective use of the medication.