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This safety and warning guide outlines the critical precautions and risks associated with the use of ertapenem (Invanz). Please read carefully and discuss any concerns with your healthcare provider.

• Allergic Reactions: There is a possibility of allergic reactions to ertapenem (Invanz), which can be severe and life-threatening, such as hives, facial swelling, shock, and anaphylaxis. Inform your healthcare provider if you have a known allergy to antibiotics to ensure ertapenem is safe for you. Seek immediate medical attention if you experience hives, rash, skin redness, swelling of the lips or tongue, or difficulty breathing during treatment. This risk is heightened if you have allergies to penicillin or cephalosporin antibiotics.

• Nervous System Side Effects: Though uncommon, some individuals may experience serious nervous system side effects, including seizures, delirium, and hallucinations. If you or someone close to you notices these symptoms, contact emergency services immediately. These effects typically subside once the medication is discontinued. Those with a history of seizures, brain issues, kidney problems, or who are taking valproic acid or divalproex sodium are at greater risk.

• Diarrhea from Clostridioides difficile Infection: Ertapenem (Invanz) and other antibiotics can increase the risk of infection with Clostridioides difficile (C. diff) due to changes in gut bacteria. This can lead to severe diarrhea, which may be life-threatening.

• Development of Drug-Resistant Bacteria: It is crucial to adhere to the prescribed duration and purpose of ertapenem (Invanz) treatment. Deviating from these guidelines can increase the risk of developing infections with drug-resistant bacteria, which are more difficult to treat and potentially life-threatening.

Contraindications:

• Do not use ertapenem (Invanz) if you have an allergy to penicillins, cephalosporins, or other beta-lactam antibiotics.
• Avoid use if you are allergic to local anesthetics like lidocaine, especially during intramuscular administration.

Always consult with your healthcare provider to ensure this medication is appropriate for your condition and to discuss any potential risks or concerns.

Common side effects:

• Swelling at the injection site
• Redness at the injection site
• Pain at the injection site
• Soreness at the injection site
• Upset stomach
• Headache
• Nausea
• Vomiting
• Diarrhea
• Vaginal irritation

Less common but important to monitor:

• Stomach pain
• Dizziness
• Itching
• Rash
• Shortness of breath

Serious side effects:

• Severe allergic reactions
• Hives
• Blisters
• Skin reddening
• Swelling of the lips or tongue
• Trouble breathing
• Hallucinations
• Seizures
• Confusion
• Severe intestinal condition due to C. difficile
• Persistent diarrhea
• Abdominal pain
• Blood in stools
• Oral thrush
• New yeast infection
• White patches in the mouth
• Changes in vaginal discharge

Interactions with high risk of serious adverse effects and should be avoided:

• Valproic Acid
• Divalproex Sodium
• Sodium Valproate

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Cholera Vaccine, Live
• Probenecid
• Tacrolimus