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The following safety information outlines the critical warnings and precautions associated with using mupirocin. Please read carefully and consult your healthcare provider for any questions or concerns.

• Severe Allergic Reaction: Although rare, mupirocin can trigger severe or life-threatening allergies. Discontinue use immediately and seek emergency medical assistance if you experience symptoms such as rash, hives, swelling, or difficulty breathing, which could indicate anaphylaxis.

• Diarrhea from Clostridioides difficile Infection: There is a potential risk of diarrhea caused by Clostridioides difficile (C. diff) infection when using mupirocin. Like other antibiotics, it can alter the balance of normal gut bacteria, allowing C. diff to proliferate. However, because mupirocin is typically applied to the skin, absorption into the body is minimal.

• Development of Hard-to-Treat Infections: Prolonged use of mupirocin may lead to the development of bacteria or fungi resistant to treatment, resulting in infections that are challenging to manage. To minimize this risk, follow your healthcare provider's directions and avoid using the medication longer than prescribed.

• Use Caution in Individuals with Kidney Problems (Ointment Only): The ointment form of mupirocin contains an inactive ingredient that could be harmful if absorbed in significant quantities, particularly through damaged skin. This is of particular concern for individuals with kidney issues, as the kidneys are responsible for eliminating this substance from the body.

For comprehensive safety, adherence to these guidelines and close communication with your healthcare provider are essential in managing your treatment with mupirocin effectively.

When using this medication, some individuals may experience common side effects. These include headaches, mild burning, stinging, or pain at the application site, and occasionally, a rash or nausea. If these symptoms persist or become bothersome, consider consulting your healthcare provider for advice.

In some cases, other side effects such as itching, skin irritation, or dizziness may occur. While these are generally not serious, it's important to monitor your symptoms and reach out to a healthcare professional if they worsen.

There are rare but serious side effects associated with this medication that require immediate medical attention. A severe allergic reaction can manifest as rash, hives, significant swelling, or difficulty breathing. Additionally, a serious intestinal condition, potentially caused by C. difficile bacteria, may occur and is characterized by persistent diarrhea, abdominal pain, or blood in the stool. If you experience any of these, seek urgent medical help.

Prolonged use of the medication may lead to a new skin infection from fungus or yeast. Report any new or worsening infections to your healthcare provider promptly. Always be vigilant and contact your healthcare provider if you notice any unusual symptoms not listed here.