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The following safety information highlights important warnings and contraindications associated with the use of Augmentin (amoxicillin/clavulanate). Please read these carefully and discuss any concerns with your healthcare provider.

• Severe Allergic Reactions and Skin Reactions: Augmentin can trigger severe allergic reactions, including life-threatening conditions such as facial swelling and anaphylaxis, which can cause the throat to close. If you have any known allergies to antibiotics, particularly penicillin, inform your healthcare team to assess your risk.

• Liver Issues: While uncommon, Augmentin may lead to serious liver complications. These issues are generally reversible but can occasionally be life-threatening. If you have a history of liver problems, it is essential to notify your healthcare provider. You might require blood tests to monitor your liver function.

• Clostridioides difficile Infection-Associated Diarrhea: The use of Augmentin can increase the risk of a C. difficile infection due to alterations in the natural bacterial flora of the stomach and intestines. This can lead to an overgrowth of C. diff, resulting in infection and severe diarrhea.

• Phenylketonuria (PKU) Considerations: Certain formulations of Augmentin, such as chewable tablets and oral suspensions, contain phenylalanine due to the inclusion of the artificial sweetener aspartame. If you have PKU, using these specific forms may be harmful.

Contraindications:

• Severe Beta-Lactam Antibiotic Allergy: Do not use Augmentin if you have a severe allergy to beta-lactam antibiotics, including penicillin and cephalexin.

• History of Liver Problems with Augmentin: Avoid this medication if you have previously experienced liver issues related to taking Augmentin.

In case of an overdose or any adverse reaction, seek immediate medical attention. Always consult your healthcare professional before starting or stopping this medication to ensure it is safe for your use.

When using this medication, some individuals may experience mild side effects such as diarrhea or loose stools, nausea, and skin rash. These are generally not serious, but if they persist or become bothersome, it's advisable to consult a healthcare provider. Taking the medication with food can help minimize stomach upset.

In some cases, more significant side effects can occur, and medical attention may be necessary. This includes symptoms of liver disease like persistent nausea or vomiting, loss of appetite, stomach pain, yellowing of the eyes or skin, dark urine, easy bruising or bleeding, and unusual tiredness. A severe intestinal condition caused by the bacteria C. difficile is also possible, with symptoms such as persistent diarrhea, abdominal pain, and blood or mucus in the stool. In such instances, avoid using anti-diarrhea or opioid products as they can exacerbate the symptoms.

Long-term use of the medication might lead to oral thrush or a new yeast infection, indicated by white patches in the mouth, changes in vaginal discharge, or other new symptoms. While an allergic reaction to this drug is rare, serious symptoms like fever, lymph node swelling, rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing require immediate medical care.

It's worth noting that amoxicillin can commonly cause a mild rash, which is usually not serious, but it can be difficult to distinguish from a rash that signals a severe allergic reaction. It's crucial to seek medical help if any rash develops. Always report any new or unusual symptoms to a healthcare provider, ensuring to get appropriate guidance and care.

Augmentin (amoxicillin/clavulanate) can interact with a variety of medications, so it is important to inform your doctor and pharmacist about all the drugs and supplements you are currently using, including prescription, over-the-counter, vitamins, and herbal products.

One specific drug that may interact with Augmentin is Methotrexate. Additionally, Augmentin can interfere with certain laboratory tests, such as urine glucose tests, potentially leading to incorrect results. Therefore, ensure that all healthcare providers and lab personnel are aware that you are taking this medication.

There are several medications that are generally not recommended to be used with Augmentin unless necessary. If they are prescribed together, your doctor might need to adjust dosages or the frequency of use. These include Chlortetracycline, Cholera Vaccine Live, Demeclocycline, Desogestrel, Dienogest, Doxycycline, Drospirenone, Eravacycline, Estradiol, Ethinyl Estradiol, Ethynodiol, Gestodene, Levonorgestrel, Lymecycline, Meclocycline, Mestranol, Methacycline, Minocycline, Mycophenolate Mofetil, Nomegestrol, Norethindrone, Norgestimate, Norgestrel, Omadacycline, Oxytetracycline, Rolitetracycline, Sarecycline, Sulfasalazine, Tetracycline, Tigecycline, Venlafaxine, and Warfarin.

Moreover, using Augmentin with medications like Acenocoumarol, Khat, and Probenecid may increase the risk of certain side effects. However, sometimes combining these drugs can be beneficial, and your doctor may adjust treatment accordingly. Always follow your healthcare provider’s instructions when taking Augmentin with other medications.