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The use of Clenpiq is accompanied by several important safety considerations. It is crucial to understand these potential risks and precautions to ensure safe usage. If you have any concerns or questions, please discuss them with your healthcare provider.

• Dehydration and Electrolyte Imbalances: Clenpiq may lead to reduced fluid and electrolyte levels, potentially resulting in severe side effects such as abnormal heart rhythms, seizures, significant kidney issues, fainting, and falls. This risk increases if you are taking medications that affect fluid and electrolyte balance or if you have kidney problems.

• Seizures: There have been reports of seizures in individuals using bowel preparation medications like Clenpiq, even if they had no previous history of seizures. These incidents are generally linked to electrolyte imbalances. Higher risk exists for those with a history of seizures, electrolyte imbalance, low sodium levels, those taking seizure-promoting medications, or those withdrawing from alcohol or benzodiazepines.

• Kidney Health: Notify your healthcare team if you have kidney issues before starting Clenpiq, as there is a potential risk for worsening kidney injury or electrolyte disturbances. Some medications can exacerbate these risks, so consult your provider about any drugs you should avoid.

• Heart Rhythm Changes: Although rare, severe cardiac arrhythmias have been reported with the use of osmotic laxatives like Clenpiq. Those with heart conditions, such as a recent heart attack or congestive heart failure, should inform their care team. An electrocardiogram (ECG) might be recommended before and after the procedure to monitor heart rhythm.

• Gastrointestinal Issues: Clenpiq can cause significant stomach and bowel problems, including blockages and potential damage to the gut wall. Avoid using other stimulant laxatives concurrently, as this increases the risk of gastrointestinal issues.

• Choking Hazard: Discuss with your gastroenterologist if you have gag reflex issues, as there is a risk of regurgitation or aspiration of the medication into the lungs.

Contraindications: Clenpiq should not be used if you have severe kidney issues, intestinal blockages, colon inflammation or swelling, difficulty in emptying your stomach, or any perforations in the bowel wall. Consult your healthcare provider if any of these conditions apply to you.

When taking this medication, some individuals may experience common side effects such as nausea, headache, stomach pain, and mild dehydration or dizziness. These effects are generally mild and manageable, but if they persist or worsen, consulting a healthcare provider is advisable.

Other side effects that have been reported include vomiting, rash, and itchy skin. Some may also experience an inability to control bowel movements, anal and rectal pain, and changes in electrolyte levels. While these are less common, it is important to monitor them and consult a healthcare provider if they become problematic.

There are rare but serious side effects associated with this medication that require immediate medical attention. These include severe dehydration characterized by symptoms like dizziness, lightheadedness, headache, dry mouth, vomiting, or fainting. Signs of kidney problems, such as reduced urination, swelling in the arms and legs, tiredness, or nausea, should also prompt urgent care. Abnormal heart rhythms, which may present as a fast heartbeat, dizziness, tiredness, weakness, chest pain, or sweating, are critical and warrant immediate medical intervention. Seizures, although rare, are also a severe side effect that needs urgent attention. Lastly, while a very serious allergic reaction is rare, symptoms such as rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing require immediate medical help.