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Understanding the safety and warning information for Lactulose (Constulose) is crucial for its safe use. Below is a summary of important considerations related to potential risks, precautions, and specific instructions for certain populations.

• Dehydration and Electrolyte Imbalance: Lactulose (Constulose) may lead to dehydration, impacting your body's mineral levels, such as sodium, potassium, and calcium. It is advisable to have regular electrolyte checks, especially for older adults or those using lactulose for extended periods. Immediately contact your healthcare provider if you experience extreme thirst, fatigue, or confusion, as these may signal dehydration and electrolyte imbalance. Key risk factors include long-term use (over 6 months), age 65 and above, and concurrent use of medications causing electrolyte disturbances.

• Blood Sugar Concerns: Lactulose (Constulose) includes sugars like galactose and lactose. If you have diabetes or are concerned about blood sugar levels, it is prudent to monitor your levels regularly. Although studies suggest lactulose does not significantly raise blood sugar, caution is advised.

• Colonoscopy and Rectal Exams: If a colonoscopy or rectal exam is scheduled, inform your healthcare team that you are taking Lactulose (Constulose). Your provider may recommend alternative medications for bowel preparation prior to the procedure.

• Dietary Considerations: This medication is contraindicated for individuals on a low-galactose diet, as it might pose significant health risks. Consult your healthcare provider if this applies to you.

These considerations are essential to ensure the safe use of Lactulose (Constulose). Always consult your healthcare provider with any concerns or questions.

Common side effects:

• gas
• bloating
• burping
• stomach rumbling
• mild stomach cramps

Less common but important to monitor:

• nausea
• vomiting
• diarrhea

Serious side effects:

• severe abdominal pain
• persistent diarrhea
• muscle cramps or weakness
• irregular heartbeat
• mental or mood changes
• seizures
• bloody stools
• rectal bleeding
• rash (allergic reaction)
• itching (allergic reaction)
• swelling of the face, tongue, or throat (allergic reaction)
• severe dizziness (allergic reaction)
• difficulty breathing (allergic reaction)

Interactions with high risk of serious adverse effects and should be avoided:

• Amantadine
• Atropine
• Belladonna
• Benztropine
• Dicyclomine
• Cisapride
• Dronedarone
• Eplerenone
• Glycopyrrolate
• Solifenacin
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Acalabrutinib
• Amiodarone
• Amitriptyline
• Amphetamine
• Aripiprazole
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Erythromycin
• Fluconazole
• Lisinopril
• Methadone
• Tacrolimus
• Antacids containing aluminum and/or magnesium
• Other laxatives