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The following information outlines essential safety considerations and warnings regarding the use of Colestipol (Colestid). It is crucial to understand these details and consult with your healthcare provider if you have any questions or concerns.

• Choking Risk: There is a significant risk of choking when Colestipol granules for suspension are consumed in their dry form. Always mix the granules with at least 3 ounces of liquid before ingestion. Additionally, swallowing multiple tablets simultaneously rather than one at a time can also increase the choking risk. If you experience swallowing difficulties or feel any pressure or discomfort in your throat after taking the medication, contact your healthcare provider immediately. This is particularly important for individuals with pre-existing swallowing issues or anatomical changes in the digestive tract.

• Vitamin Absorption: Colestipol may reduce the absorption of vitamins A, D, E, K, and folic acid. It is advisable to discuss with your healthcare provider whether you need vitamin supplements to maintain healthy levels. If supplements are recommended, they should be taken at least 1 hour before or 4 hours after Colestipol to prevent interference with vitamin absorption.

• Increased Bleeding Risk: Long-term use of Colestipol or concurrent use with blood thinners can elevate the risk of bleeding due to potential vitamin K deficiency. Be vigilant for symptoms such as unexplained bruising, blood in stools, or prolonged bleeding and report these to your healthcare provider promptly.

• Medication Interaction: To prevent potential interactions, other oral medications should be taken at least 1 hour before or 4 hours after taking Colestipol. This is crucial as Colestipol can affect the absorption and effectiveness of other drugs, such as birth control pills and thyroid medications.

• Phenylketonuria (PKU) Caution: The granules for oral suspension may contain phenylalanine, which is harmful to individuals with PKU due to its presence as a component of aspartame. Consult with your pharmacist if you have PKU to ensure the formulation you have is safe, as alternative formulations may be available.

Always follow your healthcare provider's instructions and discuss any potential risks or concerns associated with the use of Colestipol.

When taking this medication, you might experience some mild side effects such as constipation, gas, bloating, stomach pain, cramps, heartburn, nausea, or vomiting. These are generally manageable and can often be alleviated with dietary adjustments, like increasing fiber intake, staying hydrated, and regular exercise. A laxative might also help with constipation; consult a pharmacist for suitable options.

However, if these symptoms persist or worsen, it’s important to seek advice from a healthcare provider. In rare cases, more serious side effects may occur, which require immediate medical attention. These include severe stomach pain, unusual bleeding or bruising, rapid breathing, confusion, or signs of a digestive tract blockage such as severe constipation and blood in your stool.

Additionally, although a very serious allergic reaction is rare, be vigilant for symptoms like rash, itching, swelling, severe dizziness, or trouble breathing, and seek emergency medical help if they occur. Always remain observant of any unusual symptoms and consult your healthcare professional for guidance.

Colestipol (Colestid) may interact with several medications. It's important to inform your doctor and pharmacist about any drugs or supplements you're taking, including prescription, over-the-counter, vitamins, and herbal products. Some key interactions include:

• Blood Thinners: Like Warfarin, they might interact with colestipol.

• Mycophenolate Products: Including mycophenolate mofetil and Mycophenolic Acid, may have interactions.

• Raloxifene: This can also interact with colestipol.

Additionally, colestipol may not be recommended with medications such as bezafibrate, Deferasirox, and Digoxin unless deemed necessary, in which case your doctor might adjust the dosages. For drugs like aceclofenac, Diclofenac, diltiazem, Ezetimibe, Fenofibrate, Furosemide, Hydrocortisone, and tetracycline, there might be an increased risk of side effects. In such scenarios, your healthcare provider may alter how you use one or both medications to ensure safety and efficacy.