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This medication carries several important safety warnings that you should be aware of to ensure its safe use. Please read the following information carefully and discuss any concerns with your healthcare provider.

• Choking Hazard: To prevent choking, never consume colestipol (Colestid) granules in their dry form. Always mix them with at least 3 ounces of liquid before consumption. Avoid swallowing multiple tablets simultaneously; instead, take them one at a time. If you have existing swallowing difficulties or anatomical changes in your digestive tract, discuss with your prescriber if this medication is suitable for you. Contact your healthcare provider immediately if you experience any throat discomfort or pressure after taking the medication.

• Vitamin Absorption: Colestipol (Colestid) can impair the absorption of vitamins A, D, E, and K, as well as folic acid, potentially leading to deficiencies. Consult your healthcare provider about the need for vitamin supplements. If supplements are recommended, ensure they are taken at least one hour before or four hours after your colestipol dose to avoid interference.

• Bleeding Risk: There is an increased risk of bleeding associated with colestipol (Colestid), especially due to potential vitamin K deficiency. This risk is heightened with long-term use or concurrent use of blood thinners. Report any unusual bruising, blood in stools, or prolonged bleeding to your healthcare provider immediately.

• Drug Interactions: To prevent interactions, take other oral medications at least one hour before or four hours after colestipol (Colestid). This medication can affect the absorption and efficacy of other drugs, including birth control pills and thyroid medications.

• Phenylketonuria (PKU) Caution: If you have phenylketonuria (PKU), be cautious with the granules for suspension form of colestipol (Colestid), as it may contain phenylalanine from aspartame. Consult your pharmacist to confirm whether your formulation is safe, and seek alternatives if necessary.

If you have further questions or need clarification about these warnings, please contact your healthcare provider for additional guidance.

Common side effects:

• Constipation
• Gas
• Bloating
• Stomach pain
• Cramps
• Heartburn
• Nausea
• Vomiting
• Diarrhea

Serious side effects:

• Severe stomach or abdominal pain
• Unusual bleeding or bruising
• Rapid breathing
• Confusion
• Blockage in the digestive tract
• Severe allergic reactions (rash, itching or swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Bezafibrate
• Deferasirox
• Digoxin
• Mycophenolate Mofetil
• Mycophenolic Acid

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Blood thinners (such as warfarin)
• Mycophenolate

Interactions with low risk that usually do not require a change in therapy:

• Aceclofenac
• Diclofenac
• Diltiazem
• Ezetimibe
• Fenofibrate
• Furosemide
• Hydrocortisone
• Tetracycline
• Raloxifene