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This medication carries important safety information regarding its use and potential risks. It is crucial to understand these warnings and consult with your healthcare provider if you have any questions or concerns. Below are the key safety considerations:

• Blood Clots and Cardiovascular Risks: Estrogen-containing medications, such as Covaryx (esterified estrogens / methyltestosterone), can increase the risk of blood clots, which may lead to serious conditions such as deep vein thrombosis, pulmonary embolism, heart attack, or stroke. This risk is heightened in individuals with a personal or family history of blood clots, heart disease, high blood pressure, diabetes, high cholesterol, those who smoke, or have systemic lupus erythematosus (SLE). Discuss with your doctor the need for this medication and use it at the lowest effective dose for the shortest duration.

• Cancer Risks: Use of estrogen therapy, including Covaryx, may raise the risk of breast, uterine, or endometrial cancer. The risk is particularly significant with long-term use or when estrogen is taken without a progestin. Regular breast examinations and mammograms are advised. Contact your healthcare provider if you notice any unusual changes in your breasts or experience unusual vaginal bleeding.

• Pregnancy and Reproductive Health: Covaryx should not be used by individuals who are pregnant or may become pregnant, as it may harm the fetus. Women of childbearing potential should discuss effective contraceptive measures with their healthcare provider.

• Liver and Gallbladder Health: Estrogens may increase the risk of liver damage and gallbladder disease. Methyltestosterone, a component of Covaryx, can also cause severe liver damage. Symptoms like jaundice, stomach pain, or dark urine should prompt immediate consultation with a healthcare provider.

• Calcium Levels in Blood: This medication can lead to elevated calcium levels, particularly in individuals with breast cancer or bone metastases. Regular monitoring of calcium levels is advised, and any symptoms such as fatigue or muscle weakness should be reported to your healthcare provider.

• Fluid Retention: Covaryx may cause fluid retention, exacerbating conditions such as heart failure, kidney damage, or liver disease. Be vigilant for signs like sudden weight gain or limb swelling, and report them to your healthcare provider.

Contraindications: Do not use this medication if you have a history of breast cancer (except in certain metastatic cases), estrogen-sensitive tumors, current pregnancy or breastfeeding, abnormal vaginal bleeding, blood clotting issues, or severe liver damage. Consult your healthcare provider if any of these apply to you.

In case of overdose, seek emergency medical attention immediately. Regular check-ups, including physical examinations, are essential to monitor your health while using this medication. Always follow your healthcare provider's guidance regarding the use of this medication.

When taking this medication, some individuals may experience common side effects such as dizziness, lightheadedness, headache, stomach upset, bloating, nausea, and changes in menstrual bleeding patterns. Other common symptoms include menstrual cramps, premenstrual-like syndrome, breast tenderness or enlargement, and acne. While these side effects are generally mild, it is important to inform your healthcare provider if they persist or worsen.

In some cases, users may notice changes in weight, sex drive, or hair growth, as well as depression, anxiety, or swelling in the feet or ankles. Darkened patches of skin on the face and vaginal yeast infections have also been reported. If any non-severe side effects become bothersome, discussing them with your healthcare provider can be helpful.

It is crucial to be aware of rare but serious side effects that require immediate medical attention. These include symptoms of blood clots, such as trouble breathing, leg pain, swelling, or skin warmth; heart attack signs like chest or arm pain, shortness of breath, cold sweat, or lightheadedness; and stroke indicators such as sudden weakness on one side of the body, facial drooping, speech or vision changes, confusion, or headache. Additionally, report any breast lumps or pain, unusual vaginal bleeding, or symptoms of high calcium levels, such as tiredness, muscle weakness, nausea, or frequent urination.

Women might experience signs of masculinization, such as deepening of the voice, facial hair growth, or an enlarged clitoris. If these occur, stop taking the medication and seek medical advice immediately. Lastly, though rare, a serious allergic reaction can occur, with symptoms like rash, itching, swelling, severe dizziness, or trouble breathing. Seek urgent medical care if these symptoms develop. Always communicate any concerning symptoms to your healthcare provider for guidance.

Covaryx (which contains esterified estrogens and Methyltestosterone) can interact with a range of medications and supplements. It is important to inform your healthcare provider about all medications and supplements you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal products.

Certain drugs, such as Anastrozole, corticosteroids (e.g., Prednisone), Exemestane, fezolinetant, ospemifene, Raloxifene, Tamoxifen, and Tranexamic Acid, might interact with Covaryx. Additionally, medications like Warfarin, a blood thinner, should be used cautiously as they may require dosage adjustments or close monitoring when taken with Covaryx.

Other medications that could affect how Covaryx works include those that influence the elimination of estrogens from your body. These include azole antifungals (like Itraconazole), macrolide antibiotics (such as Erythromycin), rifamycins (like Rifabutin), St. John's wort, and drugs used for seizure control (such as Carbamazepine and Phenytoin).

Furthermore, Covaryx may interact with medications like amifampridine, anisindione, bupropion, dicumarol, Donepezil, and phenprocoumon. Your doctor might adjust the dosage or frequency of these medications if used alongside Covaryx.

Finally, using Covaryx with Ginseng, Levothyroxine, licorice, tipranavir, or warfarin could heighten the risk of side effects. Even so, these combinations might be necessary for your treatment, and your doctor will manage the dosages appropriately. Additionally, Covaryx may interfere with certain laboratory tests, potentially leading to inaccurate results, so ensure all healthcare professionals involved in your care are aware of your Covaryx use.