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When using estrogen, whether alone or combined with another hormone like progestin for postmenopausal hormone replacement therapy, there is a potential for rare but serious side effects. It is crucial to evaluate the risks and benefits of hormone therapy with your healthcare provider, taking into account your personal medical history.

• Estrogens have been associated with an increased risk of uterine cancer (endometrial cancer). However, combining estrogen with progestin helps reduce this risk. Notify your doctor immediately if you experience any unusual vaginal bleeding.
• In postmenopausal women, estrogens, with or without progestin, can elevate the risk of breast and ovarian cancers, stroke, dementia, and severe blood clots. When used with progestin, the risk of heart disease, including heart attacks, also increases. These risks may be influenced by the duration and dosage of estrogen therapy. Aim to use this medication for the shortest duration at the lowest effective dose to balance benefits and reduce the likelihood of serious long-term side effects. Regular discussions with your doctor, ideally every 3 to 6 months, are important to assess the ongoing need for this medication.
• Estrogen products should not be used to prevent heart disease or dementia.
• If you continue to use this medication over a long period, ensure that you undergo a comprehensive physical examination regularly, such as annually, or as advised by your physician.

Always consult with your healthcare provider for personalized guidance and to address any concerns you may have regarding estrogen therapy.

When taking this medication, you might experience dizziness, lightheadedness, headaches, stomach upset, bloating, or nausea. Changes in weight, fluctuations in sexual interest, or breast tenderness are also possible, but these are generally mild. If these symptoms persist or worsen, it's important to inform your healthcare provider.

Monitoring blood pressure is crucial as this medication may cause an increase. If your readings are high, seek advice from your healthcare provider who may recommend management strategies.

Some serious side effects require immediate attention. These include signs of liver issues such as persistent nausea, yellowing skin or eyes, abdominal pain, and dark urine. Mental health changes, breast lumps, unusual swelling, abnormal vaginal bleeding, or discharge should also be promptly reported.

Women may notice signs of masculinization, such as voice changes, increased facial hair, or acne. Immediate discontinuation and medical consultation are advised if these symptoms appear.

Rarely, this medication can lead to serious blood clot issues, potentially resulting in heart attacks or strokes. Seek emergency care if you experience chest pain, shortness of breath, sudden dizziness, or severe headaches.

Allergic reactions are uncommon but can be severe. Symptoms like rash, swelling, or difficulty breathing require urgent medical attention. If you encounter any other unusual effects, consult your healthcare provider.