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This medication comes with important safety considerations and warnings that should be thoroughly reviewed to ensure safe use. Please consult with your healthcare provider if you have any questions or concerns about the following information:

• Smoking and Cardiovascular Risks: If you are a smoker, particularly if you are over 35 years of age, using hormonal birth control like Cryselle increases your risk of serious health issues, including stroke, heart attack, and blood clots. It is advised to discuss alternative birth control methods with your healthcare provider.

• Blood Clots and Strokes: Cryselle may elevate the risk of developing blood clots, which can lead to severe conditions such as pulmonary embolism, deep vein thrombosis, stroke, or heart attack. Immediate medical assistance is necessary if you experience symptoms indicative of a blood clot. Risk factors include smoking, age over 35, recent surgery involving prolonged bed rest, postpartum initiation, high blood pressure, obesity, high cholesterol, diabetes, and higher estrogen doses.

• Cancer Risks: There is a potential link between Cryselle and an increased risk of breast and cervical cancers, especially with a history of breast cancer or long-term use of the medication.

• Liver Concerns: Rarely, Cryselle can lead to liver problems, including liver damage and tumors. Avoid this medication if you have existing liver issues, and seek immediate medical attention if you notice symptoms such as fatigue, abdominal pain, or jaundice.

• Blood Sugar and Triglycerides: This medication may raise blood sugar and triglyceride levels. Those with prediabetes or diabetes should monitor their blood sugar levels closely and attend regular medical check-ups.

• Blood Pressure: Cryselle can cause an increase in blood pressure. Regular monitoring is recommended, and those with uncontrolled high blood pressure should consider alternative contraceptives.

• Headaches: While headaches are a common side effect, any new or worsening migraines, or severe recurring headaches should be assessed by a healthcare provider.

• Irregular Bleeding: Breakthrough bleeding and spotting are common, especially in the initial months of use. Alert your healthcare provider if there are changes in your menstrual cycle.

• Depression: Report any new or worsening symptoms of depression to your healthcare provider. In severe cases, discontinuation of Cryselle may be necessary.

• Gallbladder Issues: Cryselle may slightly increase the risk of gallbladder disease. Discuss your medical history with your healthcare provider before starting this medication.

• Drug Interactions: Some medications can decrease the effectiveness of Cryselle, leading to potential pregnancy. Examples include carbamazepine and phenytoin. Use a backup contraceptive method for at least 28 days after discontinuing these drugs. Inform your healthcare provider of all medications you are taking to avoid interactions.

Contraindications: Do not use Cryselle if you have any of the following conditions, as it may pose serious health risks. Consult your healthcare provider if any apply:

• History of deep vein thrombosis, pulmonary embolism, or other clotting disorders.
• Smoking and age over 35.
• Cerebrovascular or coronary artery disease.
• Certain heart valve or rhythm conditions.
• Diabetes with vascular complications.
• Specific headaches with neurological symptoms.
• Migraines with aura and age over 35.
• Uncontrolled hypertension.
• History of hormone-sensitive breast cancer.
• Undiagnosed abnormal vaginal bleeding.
• Liver tumors or disease.
• Pregnancy.
• Use of certain hepatitis C medications.

Always consult with your healthcare provider before starting or stopping any medication.

When taking this medication, some common side effects you might experience include nausea, vomiting, headache, bloating, breast tenderness, and fluid retention, which can lead to swelling of the ankles or feet and changes in weight. Spotting or irregular periods may occur, especially when you first start using the medication. Additionally, some individuals report back pain, vaginal discharge, acne, a larger appetite, and nervousness. While these effects are typically mild, it is important to speak with your healthcare provider if they persist or worsen.

There are some other side effects such as darker skin patches, fatigue, and aggravated varicose veins. If you experience any of these, consult your healthcare provider for advice. More serious side effects, though rare, include lumps in the breast, mental or mood changes like worsening depression, severe abdominal pain, or unusual vaginal bleeding patterns. These warrant immediate medical attention.

This medication can also increase the risk of blood clots, which can lead to serious conditions like heart attacks, strokes, or pulmonary embolism. Symptoms of these conditions include chest pain, sudden dizziness, confusion, shortness of breath, and sudden severe headaches. If you notice any signs of these serious issues, seek urgent medical care. Additionally, be alert for signs of liver problems like yellowing of the skin or eyes and dark urine, as well as any severe allergic reactions such as rash or difficulty breathing. Always consult your healthcare provider if you notice any side effects not listed here.