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The use of this medication requires careful consideration due to potential health risks. Below are key safety warnings and precautions to keep in mind. Please consult your healthcare provider for personalized advice.

• Cigarette Smoking and Heart Health: If you're a female over 35 who smokes, using combined oral contraceptives like Yasmin significantly heightens the risk of strokes, heart attacks, and blood clots. It is advised to discuss safer birth control options with your provider if you smoke.

• Risk of Blood Clots and Stroke: Yasmin can increase the risk of developing blood clots in various parts of the body, such as the lungs (pulmonary embolism), legs (deep vein thrombosis), brain (stroke), and heart (heart attack). Immediate medical attention is required if signs of a blood clot appear. Increased risk factors include being over 35 and smoking, recent surgery with prolonged bed rest, use within a month after childbirth, high blood pressure, obesity, diabetes, and higher estrogen doses.

• Cancer Risks: There may be an elevated risk of breast and cervical cancer associated with Yasmin and other oral contraceptives, particularly in individuals with a history of breast cancer or prolonged use of COCs.

• Liver Health Concerns: Although rare, Yasmin may cause liver damage or tumors. This risk is more pronounced with older contraceptives containing higher estrogen levels. It's crucial to avoid use if you have existing liver problems and to seek medical advice if symptoms like fatigue, abdominal pain, or jaundice occur.

• Blood Pressure Monitoring: Yasmin can lead to increased blood pressure. Regular monitoring is recommended, and those with uncontrolled hypertension should consider alternative contraceptives.

• Blood Sugar and Lipid Levels: Users may experience elevated blood sugar and triglycerides, particularly if there is a history of diabetes or high triglycerides. Regular check-ups are essential for monitoring these changes.

• Headaches and Migraines: Report any new or worsening headaches or migraines to your healthcare provider promptly.

• Depression Monitoring: Inform your provider of any depressive symptoms or worsening mental health conditions. Discontinuation might be necessary for severe depression.

• Drug Interactions: Certain medications can reduce Yasmin's effectiveness, increasing the risk of pregnancy. Examples include carbamazepine and phenytoin. Use additional contraception methods for at least 28 days after stopping these medications. Other drugs may increase Yasmin's concentration, leading to more side effects. Always inform your healthcare provider of all medications you are taking.

• Potassium Levels: Yasmin contains drospirenone, which can raise potassium levels, especially when taken with medications that increase potassium. Regular monitoring of potassium levels is suggested, particularly for those with kidney, liver, or adrenal issues.

Contraindications:

• Yasmin should not be used if you have issues with the kidneys, liver, or adrenal glands, are over 35 and smoke, have a high risk of blood clots, or have blood vessel problems affecting the heart or brain. Additional contraindications include undiagnosed abnormal uterine bleeding, certain heart conditions, uncontrolled high blood pressure or diabetes, pregnancy, current or previous hormone-sensitive breast cancer, headaches involving the spine or brain, migraines with or without aura if over 35, liver tumors, or current treatment with Viekira Pak (dasabuvir / ombitasvir / paritaprevir / ritonavir).

Common side effects:

• Nausea
• Vomiting
• Headache
• Bloating
• Breast tenderness
• Swelling in the ankles or feet due to fluid retention
• Weight changes
• Premenstrual symptoms
• Vaginal bleeding between periods
• Changes in menstrual cycle

Serious side effects:

• Heart attacks
• Strokes
• Deep vein thrombosis
• Chest pain
• Unusual sweating
• Severe headaches
• Sudden dizziness
• Swelling and pain in the legs
• Difficulty breathing
• Sudden vision changes
• Weakness on one side of the body
• Changes in mood or mental state
• Severe abdominal pain
• Signs of liver issues (dark urine, yellowing of skin or eyes)
• Severe allergic reaction (rash, swelling, difficulty breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Boceprevir
• Dasabuvir
• Ombitasvir
• Paritaprevir
• Ritonavir
• Tranexamic Acid

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Amifampridine
• Amoxicillin
• Amprenavir
• Armodafinil
• Bacampicillin
• Aliskiren
• ACE inhibitors (e.g., Enalapril, Lisinopril)
• Angiotensin receptor blockers (e.g., Losartan, Valsartan)
• Heparin
• NSAIDs (e.g., Ibuprofen, Naproxen)
• Potassium-sparing diuretics (e.g., Spironolactone)
• Griseofulvin
• Modafinil
• Rifamycins (e.g., Rifampin)
• St. John's Wort
• Seizure medications (e.g., barbiturates, Carbamazepine, Phenytoin)
• HIV drugs (e.g., nelfinavir, Nevirapine)