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Please review the following safety information regarding the use of Slynd (drospirenone). It is crucial to understand the potential risks and necessary precautions associated with this medication. Consult your healthcare provider with any questions or concerns.

• High Blood Potassium Levels: Slynd may elevate potassium levels, which is typically not concerning unless you already have high potassium due to conditions like kidney or liver issues, or are taking medications that increase potassium. Your healthcare provider might monitor your potassium levels before and during treatment. Symptoms such as a racing heart, breathing difficulties, chest pain, muscle weakness, nausea, or vomiting should be reported to your healthcare provider immediately.

• Risk of Blood Clots, Heart Attacks, and Strokes: While the risk is very low, Slynd might slightly increase the chance of blood clots. Discuss your medical history with your healthcare provider to evaluate your risk. Seek urgent medical care if you experience leg or arm pain, chest pain, severe headaches, breathing difficulties, or sudden changes in speech or vision.

• Liver Problems: Avoid using Slynd if you have liver issues, as it can increase drospirenone levels in your body. Although uncommon, progestins like Slynd may cause liver problems. Watch for symptoms like yellow skin or eyes, upper right stomach pain, or dark urine, and inform your healthcare provider if they occur.

• High Blood Sugar: Slynd might increase blood sugar levels by reducing insulin sensitivity, typically not a concern for individuals without blood sugar issues. If you have high blood sugar, your healthcare provider may monitor your levels more frequently and adjust your medication dosage if needed. Report symptoms like excessive thirst, hunger, or frequent urination to your healthcare provider.

• Menstrual Bleeding Pattern Changes: Changes in menstrual bleeding or spotting are common within the first three months of using Slynd. If these changes persist, inform your gynecologist as an adjustment to your birth control may be necessary. If you miss a period, contact your gynecologist to rule out pregnancy, possibly using a pregnancy test, especially if you missed doses.

• Ectopic Pregnancy: There is a rare risk of ectopic pregnancy if conception occurs while taking Slynd. Symptoms such as cramping or pain in the lower abdomen or shoulder require immediate medical attention.

Contraindications: Do not use Slynd if you have any of the following conditions without consulting your healthcare provider, as it may pose serious health risks:

• Kidney problems
• Adrenal gland issues
• Cervical or other hormone receptor-positive cancers
• Unexplained changes in menstrual bleeding
• Liver tumors or other liver conditions

Always follow your healthcare provider's guidance and report any unusual symptoms promptly for appropriate management.

When using this medication, you may experience some common side effects that are generally mild and manageable. These include nausea, vomiting, headaches, bloating, acne, breast tenderness, and weight gain. It's also normal to encounter irregularities such as spotting or missed periods, especially in the initial months of use. While these effects are usually temporary, consult your healthcare provider if they persist or worsen.

In some cases, other side effects might occur, such as lowered sex drive and irregular vaginal bleeding. Though less common, these reactions should be discussed with your healthcare provider if they become troublesome.

There are also rare but serious side effects that warrant immediate medical attention. These include lumps in the breast, significant mood changes, severe abdominal pain, symptoms indicating high potassium levels like muscle weakness or irregular heartbeat, dark urine, or yellowing of the eyes or skin. Additionally, an ectopic pregnancy may present with lower stomach or back pain and vaginal bleeding, which requires urgent care.

Though a severe allergic reaction is rare, it's crucial to seek emergency help if you experience rash, severe dizziness, or difficulty breathing. Always communicate with your healthcare provider about any unexpected changes in your health while using this medication.

Certain medications can interact with this drug, impacting its effectiveness and safety. For instance, atazanavir/cobicistat and fezolinetant may interact. Additionally, this medication can increase potassium levels in your blood. It's important to inform your doctor if you're taking other medications that also elevate potassium, such as aliskiren, ACE inhibitors (like enalapril or lisinopril), angiotensin receptor blockers (like losartan or valsartan), heparin, NSAIDs (such as ibuprofen or naproxen), and potassium-sparing diuretics (like eplerenone, spironolactone, or triamterene).

Some drugs might reduce the effectiveness of hormonal birth control by lowering hormone levels in your body, potentially leading to pregnancy. These include griseofulvin, modafinil, certain antibiotics like rifamycins (such as rifampin or rifabutin), ritonavir, St. John's wort, medications for seizures (such as barbiturates, carbamazepine, felbamate, phenytoin, primidone, topiramate), and some HIV treatments (like nelfinavir, nevirapine). Always consult your doctor when starting new medications and discuss the need for additional reliable birth control methods. Report any new spotting or breakthrough bleeding to your doctor, as these could indicate reduced effectiveness of your birth control.

This medication may also interfere with various lab tests, possibly leading to inaccurate results. Be sure to inform all your healthcare providers and lab technicians that you are using this medication.