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This medication comes with several important safety warnings and contraindications. It is crucial to review these details and discuss any concerns with your healthcare provider to ensure safe usage.

• Increased Eye Pressure: Glycopyrrolate (Robinul) may elevate eye pressure, particularly in individuals with glaucoma. If you experience dilated pupils, eye redness, or pain, discontinue use and contact your healthcare provider immediately.

• Heat-Related Risks: This medication reduces sweating, raising the risk of fever or heat stroke, especially in hot weather. To prevent overheating, rest in shaded areas, stay hydrated with cold water, and take breaks during physical activities. Extra caution is advised for older adults, those engaging in strenuous exercise, or taking other anticholinergic drugs.

• Potential for Stomach Blockage: Glycopyrrolate (Robinul) can lead to a stomach blockage. Persistent diarrhea could be an early signal, particularly for those with a history of intestinal surgeries, such as ileostomy or colostomy. Report prolonged diarrhea to your healthcare provider, as an alternative treatment may be necessary.

• Drowsiness and Vision Changes: The medication may cause drowsiness or blurred vision. Avoid driving or engaging in activities requiring alertness until you understand how the medication affects you. Exercise caution if you are taking other medications with similar side effects.

• Exacerbation of Pre-existing Conditions: Glycopyrrolate (Robinul) can worsen certain health conditions, such as heart diseases like congestive heart failure or hypertension, by increasing blood pressure and heart rate.

Contraindications: This medication should not be used under the following conditions due to serious health risks. Consult your healthcare provider if any of these apply to you:

• Glaucoma
• Urinary tract obstruction
• Intestinal blockages
• Reduced intestinal movement in older adults
• Inflammatory bowel disease (ulcerative colitis)
• Unstable cardiovascular status during significant blood loss
• Myasthenia gravis

Please adhere to these guidelines to minimize risks and ensure safe medication use.

This medication may cause common side effects such as drowsiness, dizziness, blurred vision, dry mouth, dry eyes, constipation, nausea, vomiting, and a feeling of bloating. Most of these effects are mild and can be managed with simple remedies like staying hydrated, using artificial tears, or consuming dietary fiber. If these symptoms persist or worsen, consult your healthcare provider for advice.

Less common side effects include reduced sweating, difficulty urinating, loss of taste, headaches, nervousness, confusion, sleepiness, insomnia, impotence, and decreased breast milk production. Although these effects might be worrisome, they often resolve on their own. However, if they continue or become uncomfortable, discussing them with your healthcare provider is advisable.

Serious side effects are rare but require immediate medical attention. These include severe allergic reactions characterized by rash, itching, swelling, or difficulty breathing; eye pain, swelling, or vision changes; and signs of toxic megacolon such as stomach pain, fever, or bloody diarrhea. Additionally, signs of worsening glaucoma like eye pain or redness should prompt urgent care.

It's important to stay informed about potential side effects and to communicate with your healthcare provider if you experience any symptoms that concern you. While the list above is not exhaustive, it covers the most significant reactions. Always seek medical advice if needed.

Certain medications and products can interact with Glycopyrrolate (Robinul), affecting how it works or increasing side effects. It is important to inform your doctor and pharmacist about all medications and supplements you are currently taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements.

Interactions to Avoid:

• Avoid using Glycopyrrolate with potassium tablets or capsules, as this combination is not recommended. Your doctor might decide to prescribe an alternative or adjust other medications you are taking.

Cautionary Interactions:

• Some medications typically should not be used with Glycopyrrolate but may be necessary in specific situations. In such cases, your doctor might adjust the dosage or frequency. These medications include, but are not limited to: aclidinium, Amitriptyline, atropine, Benztropine, Carisoprodol, Cyclobenzaprine, diphenhydramine, Donepezil, and Ipratropium.

Additional Considerations:

• Glycopyrrolate may increase drowsiness, especially when combined with other substances that have the same effect, such as opioid pain relievers (e.g., codeine, hydrocodone), alcohol, cannabis, sedatives (e.g., Alprazolam, Zolpidem), muscle relaxants, and certain antihistamines.
• Be cautious with over-the-counter products for allergies, colds, or weight loss, as they may contain ingredients that cause drowsiness or increase heart rate. Consult your pharmacist for safe use.
• This medication may affect certain lab tests, leading to incorrect results. Ensure that laboratory staff and all your healthcare providers are aware you are taking this medication.