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This information highlights important safety considerations and warnings regarding the use of Glycopyrrolate (Robinul). Please read carefully and discuss any concerns with your healthcare provider.

• Increased Eye Pressure and Glaucoma: Glycopyrrolate may elevate eye pressure, posing a risk to individuals with glaucoma. If you experience symptoms such as dilated pupils, eye redness, or pain, discontinue use and consult your healthcare provider immediately.

• Risk of Heat Stroke or Fever: This medication can reduce sweating, increasing the risk of fever or heat stroke, especially in hot weather. To prevent this, find shade, stay hydrated with cold water, and take frequent breaks during physical activities. Be particularly cautious if you are older, engaging in strenuous exercise, or taking other anticholinergic drugs.

• Stomach Blockage: Glycopyrrolate may lead to a blockage in the stomach. Persistent diarrhea could signal this condition, especially if you have a history of intestinal surgery. Contact your healthcare provider if diarrhea continues, as an alternative medication might be necessary.

• Drowsiness and Blurred Vision: This medication can cause drowsiness or blurred vision. Avoid driving or engaging in tasks requiring full attention until you understand how it affects you. Exercise extra caution if taking other medications that cause drowsiness or blurred vision.

• Exacerbation of Other Health Conditions: Glycopyrrolate can worsen certain health conditions, such as heart problems like congestive heart failure or high blood pressure, by increasing heart rate and blood pressure. Use with caution if you have such conditions.

Contraindications: Glycopyrrolate should not be used in the following conditions, as it may pose serious health risks:

• Glaucoma
• Blocked urine flow
• Stomach blockage
• Loss of intestinal muscle movement in older adults
• Inflammation of the intestines (ulcerative colitis)
• Unstable heart conditions during significant blood loss
• Abnormal muscle weakness (myasthenia gravis)

If any of the above conditions apply to you, consult your healthcare provider before using this medication.

When taking this medication, some individuals might experience common side effects such as dry mouth, constipation, dizziness, sleepiness, blurred vision, and dry eyes. These effects are usually mild, but if they persist, there are simple remedies you can try. For dry mouth, consider using sugarless hard candy, ice chips, or saliva substitutes. Increasing your dietary fiber intake, staying hydrated, and regular exercise can help alleviate constipation. If dry eyes are a concern, consult with a pharmacist about using artificial tears.

There are other side effects that might occur, such as nausea, vomiting, feeling bloated, reduced sweating, difficulty urinating, headaches, confusion, nervousness, insomnia, loss of taste, higher heart rate, impotence, and reduced breast milk production. While many of these are not serious, they can be bothersome, and it's advisable to speak with a healthcare provider if they occur.

Rare but serious side effects require immediate medical attention. These include symptoms like eye pain or redness, vision changes, seeing rainbows around lights at night, and severe allergic reactions such as rash, swelling, or trouble breathing. Serious conditions such as worsening glaucoma and toxic megacolon, characterized by severe stomach issues and fast heartbeat, also necessitate urgent care.

It’s important to be aware of these potential side effects and seek medical advice if you experience any that are persistent, bothersome, or severe. This ensures you can manage them effectively while continuing your treatment.

Glycopyrrolate, also known as Robinul, can interact with various medications and supplements. It is crucial to inform your doctor and pharmacist about all the medications and supplements you are taking, whether they are prescribed, over-the-counter, vitamins, or herbal supplements. Some drugs that may interact with glycopyrrolate include potassium tablets or capsules, as this combination is not recommended.

Additionally, medications such as pramlintide, which are affected by slowed gut movement, can also interact with glycopyrrolate. If both medications are necessary, your doctor may adjust the dosage or frequency.

Furthermore, glycopyrrolate may cause drowsiness, so be cautious if you are using other products that induce sleepiness, such as alcohol, marijuana, antihistamines (e.g., cetirizine, diphenhydramine), sleep aids, anxiety medications (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, and opioid pain relievers (e.g., codeine).

Always check the labels of all your medicines, including allergy, cough-and-cold products, and diet aids, as they might contain ingredients that cause drowsiness or a rapid heartbeat. Consult your pharmacist to ensure safe usage of these products.

Lastly, glycopyrrolate may interfere with certain laboratory tests, like gastric secretion tests, potentially leading to false results. Ensure that all laboratory personnel and healthcare providers are aware that you are using this medication.