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This document outlines critical safety information and warnings related to the use of Clarinex (desloratadine). Please read through them with care and discuss any concerns with your healthcare provider.

• Allergic Reactions: There is a risk of severe allergic reactions, including potentially life-threatening anaphylaxis, with Clarinex (desloratadine). If you have a known allergy to loratadine (found in Claritin), there is a possibility of a similar reaction to Clarinex. Seek immediate medical attention if you experience symptoms such as hives, rash, swelling of the lips or tongue, or difficulty breathing after taking this medication.

• Special Precaution for Phenylketonuria (PKU): The orally disintegrating tablets (ODTs) of Clarinex contain phenylalanine, which may pose a significant risk for individuals with phenylketonuria (PKU). It is crucial to inform your healthcare provider and pharmacist about your PKU condition before using Clarinex. Verify with your pharmacist if the prescribed formulation is appropriate for you, as alternative versions may be safer.

• Contraindications: Do not use Clarinex (desloratadine) if you are allergic to either loratadine or Clarinex itself, as this could result in serious health complications. Always consult your healthcare provider beforehand if you suspect or know of any allergies related to these substances.

Please ensure you follow these guidelines to minimize risks and maximize the effectiveness of your treatment with Clarinex.

Common side effects:

• Sore throat
• Dry mouth
• Tiredness
• Sleepiness
• Muscle pain

Less common but important to monitor:

• Fever
• Stomach upset
• Nausea
• Loss of appetite
• Diarrhea
• Trouble sleeping

Serious side effects:

• Allergic reaction
• Rash
• Itching
• Swelling
• Severe dizziness
• Difficulty breathing

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Pitolisant