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This document outlines essential safety information and warnings related to the use of desonide, a low-potency corticosteroid. Please read these points carefully and discuss any concerns with your healthcare provider.

• Hormonal Changes: Overuse of desonide can disrupt your body's natural hormone production, potentially leading to elevated blood sugar levels or increased skin bruising. Although this is uncommon due to desonide's low potency, risks increase with prolonged use or application over large skin areas. Your healthcare provider will aim to prescribe the minimum effective dose for the shortest duration. If extended use is necessary, periodic lab tests may be required to ensure normal hormone production. Avoid using desonide for more than 2 weeks (or 4 weeks for foam and gel) unless advised by a healthcare professional. Increased risk factors include concurrent use of other topical steroids, extended application, excessive dosing, use with occlusive dressings, and younger age.

• Infection Risk: Desonide can impair your immune response, increasing the risk of skin infections. It is crucial to address any existing skin infections with suitable antifungal or antibacterial treatments while using desonide. If you experience symptoms such as redness, pain, swelling, or pus at the application site, discontinue use immediately and consult your healthcare provider.

• Skin Irritation: Prolonged use of desonide beyond medical advice can lead to various skin reactions including thinning, stretch marks, spider veins, burning, itching, dryness, folliculitis, skin discoloration, or rash. To minimize these risks, adhere to the prescribed dose and duration. Notify your healthcare provider promptly if you notice any new or worsening skin issues. The risk is heightened with higher doses or extended usage.

Please note that there are no specific contraindications listed for desonide. Always follow your healthcare provider's instructions and report any unusual symptoms or concerns for timely management.

Common side effects:

• Stinging
• Burning
• Itching
• Irritation
• Dryness
• Redness
• Upper respiratory infections
• Cough
• Skin burning

Less common but important to monitor:

• Skin thinning
• Discoloration
• Acne
• Inflamed hair follicles

Serious side effects:

• Rash
• Swelling of the face, tongue, or throat
• Severe dizziness
• Difficulty breathing

Desonide is a topical corticosteroid commonly used to treat various skin conditions. While it is generally safe when used as directed, it's important to be aware of potential interactions with other medications and certain health conditions.

Drug Interactions:

Desonide may interact with other medications applied to the skin, especially those containing corticosteroids or substances that can cause skin irritation. Using multiple topical corticosteroids simultaneously can increase the risk of side effects. Therefore, it's advisable to inform your healthcare provider about all topical treatments you are using to avoid potential interactions.

Disease Interactions:

Certain health conditions can influence how your body responds to desonide:

• Diabetes: Topical corticosteroids like desonide can elevate blood sugar levels, which may be a concern for individuals with diabetes.

• Infections: Applying desonide to infected skin areas can worsen the infection. If you notice increased redness, swelling, warmth, or pain in the treated area, contact your healthcare provider promptly.

• Hyperadrenocorticism (Cushing's Syndrome): Prolonged use of topical corticosteroids over large areas or under occlusive dressings can lead to systemic absorption, potentially causing symptoms of Cushing's syndrome, such as weight gain, fatigue, and high blood pressure.

• Ocular Toxicities: Avoid applying desonide near the eyes, as it can increase the risk of eye-related side effects, including glaucoma and cataracts.

• Diaper Rash: Desonide should not be used to treat diaper rash, as the occlusive nature of diapers can enhance drug absorption, increasing the risk of side effects.

Precautions:

To minimize the risk of interactions and side effects:

• Use desonide only as prescribed by your healthcare provider.

• Avoid applying it to large areas of the body or using it for extended periods unless directed.

• Inform your healthcare provider of all medications you are currently using, including over-the-counter drugs and supplements.

• Discuss any existing health conditions with your healthcare provider before starting desonide.

By following these guidelines, you can use desonide safely and effectively while minimizing potential risks.