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Promethazine

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generic Phenergan, Promethegan

Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). It is also used with other medication to treat severe allergic reactions (anaphylaxis) and reactions to blood products. It may also be used to treat milder allergic reactions when you cannot take promethazine by mouth. It may also be used to help you feel sleepy/relaxed before and after surgery, during other procedures, or during labor and delivery. It may also be used to help certain opioid pain relievers (such as meperidine) work better. Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain. This drug is not approved for use in children younger than 2 years due to an increased risk of side effects (such as slow/shallow breathing). See also Warning section.
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WarningsPromethazine Side EffectsInteractionsFAQs

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1ML of 25MG/ML, Promethazine (1 Ampule)

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Warnings

Promethazine should not be used by children younger than 2 years because it may cause serious (possibly fatal) slow/shallow breathing. When this medication is used by children 2 years and older, use the lowest effective dosage and avoid other drugs that affect breathing. Get medical help right away if slow/shallow breathing occurs. In children, drugs for nausea should only be used in cases of prolonged vomiting of a known cause. Avoid use of promethazine in children with liver disease (including possible Reye's syndrome). This medication can cause severe tissue damage, possibly requiring surgery. Tell your health care professional right away if you have burning, pain, redness, swelling, or numbness at or near the injection site. If this occurs, the injection should be stopped and the injection site checked. It is preferred that this medication be given by injection into a muscle. There may be an increased risk of side effects if this medication is given by injection into a vein. This medication must not be given by injection under the skin.

Promethazine Side Effects

Drowsiness, dizziness, constipation, blurred vision, or dry mouth may occur. If any of these effects last or get worse, tell your doctor. To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: nausea/vomiting that doesn't stop, fainting, slow heartbeat, mental/mood changes (such as hallucinations, nervousness, irritability, restlessness, confusion), unusual/uncontrolled movements (such as fixed upward stare, neck twisting, tongue movements), shaking (tremor), difficulty urinating, easy bleeding/bruising, signs of infection (such as sore throat that doesn't go away, fever), severe stomach/abdominal pain, yellowing eyes/skin. Get medical help right away if you have any very serious side effects, including: slow/shallow breathing, seizures. This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, signs of kidney problems (such as change in the amount of urine). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

Some products that may interact with this drug include: antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray), metoclopramide. The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is used with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine). Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. This medication may interfere with certain lab tests (such as some pregnancy tests, glucose tolerance test, allergy skin testing), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
Promethazine FAQs
What is the drug promethazine used for?

Promethazine is used to treat allergy symptoms, such as itching, runny nose, and sneezing. It is also used to prevent motion sickness, treat nausea and vomiting, and as a sedative or sleep aid. Additionally, it may be used to enhance the effects of certain pain medications.

Promethazine and Zofran are not the same. Promethazine is an antihistamine used to treat allergy symptoms, nausea, and vomiting, while Zofran (ondansetron) is a selective serotonin 5-HT3 receptor antagonist used primarily to prevent nausea and vomiting caused by chemotherapy, radiation therapy, or surgery. They work differently and are used for different purposes.

A suitable substitute for Benadryl (diphenhydramine) could be another antihistamine, such as cetirizine (Zyrtec) or loratadine (Claritin). These alternatives are also used to relieve allergy symptoms and are less likely to cause drowsiness compared to Benadryl. However, it is important to consult with a healthcare provider to determine the most appropriate option based on individual needs and medical history.

Yes, promethazine is effective for treating nausea. It is an antihistamine that is commonly used to relieve symptoms of nausea and vomiting. However, it is important for individuals to use it under the guidance of a healthcare professional, as it may have side effects and interactions with other medications.

It is generally not recommended to take Benadryl (diphenhydramine) and promethazine together without consulting a healthcare provider. Both medications are antihistamines and can cause increased sedation, drowsiness, and other side effects when combined. It is important to seek advice from a healthcare professional to ensure safe use.

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