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Promethazine

Promethazine Coupons & Discount Card – Guaranteed Prices from $1.01

generic Phenergan, Promethegan

Promethazine is a versatile prescription medication primarily used to prevent and treat nausea and vomiting associated with certain conditions, such as before or after surgery and motion sickness. Additionally, it addresses allergy symptoms like a runny nose, watery eyes, rash, swelling, and anaphylaxis, particularly when oral administration isn't feasible. Promethazine is also utilized to manage pain in combination with other pain relief medications post-surgery and to help induce relaxation and light sleep before procedures or during labor. The drug functions as an antihistamine by blocking histamine, a natural substance your body produces during an allergic reaction. It also acts as an anticholinergic, affecting chemicals such as acetylcholine and dopamine to provide its anti-nausea and calming effects by acting on specific brain areas. Promethazine is available in various forms, including tablets, oral solutions, rectal suppositories, and injections. However, it is not recommended for children under two years old due to the risk of severe side effects like slow or shallow breathing. Common side effects include drowsiness and dizziness. Always consult with a healthcare professional before using promethazine or any other medication to ensure it is safe and effective for your use.
Our coupons are free to use. Before paying, show the pharmacist your Promethazine savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Promethazine prices will update based on your prescription needs. Above our Promethazine coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Promethazine at the lowest price with our prescription discount card.
Promethazine WarningsPromethazine Side EffectsPromethazine InteractionsFAQs

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1ML of 25MG/ML, Promethazine (1 Ampule)

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$20.16

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$1.01

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$2.00

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$2.48

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Promethazine dosage forms

The average cost for 1 Ampule of Promethazine (generic Phenergan, Promethegan) at 1ML of 25MG/ML is $1.01 with a free coupon. This is 92% off the average retail price of $12.67
DosageQuantityPrice fromPer unit
1ML of 25MG/ML1 Ampule$1.01$1.01
1ML of 50MG/ML1 Ampule$1.01$1.01

Promethazine Warnings

Promethazine is a medication that requires careful consideration due to its potential risks and safety concerns. Below are important safety details and precautions that must be reviewed before use:

  • Risks of Respiratory Depression: Promethazine can significantly slow down breathing, which can be life-threatening, especially in children under 2 years old or those with a history of respiratory issues. It is not recommended for children under 2. Seek immediate medical help if slow or shallow breathing occurs.

  • Injection Site Reactions: Serious tissue damage, including gangrene, can occur if promethazine is injected incorrectly, such as into an artery or under the skin. Always ensure the injection is administered into a muscle. Watch for burning, pain, redness, swelling, or skin discoloration at the injection site and seek medical attention if these occur.

  • Excessive Drowsiness: The medication can cause significant drowsiness, which may be worsened by alcohol consumption or use of other sedating drugs such as opioids or certain antidepressants. Avoid driving or operating machinery after taking promethazine.

  • Exacerbation of Existing Conditions: Promethazine may worsen certain medical conditions, including glaucoma, heart problems, enlarged prostate, breathing issues, bladder problems, stomach ulcers, and liver problems. Discuss your medical history with a healthcare provider before use.

  • Seizure Risk: Individuals with a history of seizures or those taking medications that lower the seizure threshold should use promethazine cautiously. Seek medical help if you experience symptoms like uncontrolled movements or confusion.

  • Risk of Infection: Promethazine can lower white blood cell counts, increasing infection risk, particularly in individuals undergoing chemotherapy. Notify your healthcare provider if you develop signs of infection, such as fever or chills.

  • Neuroleptic Malignant Syndrome (NMS): This rare condition can occur, especially when taken with antipsychotics. Symptoms include high fever, rapid heartbeat, stiff muscles, and confusion. Prompt medical attention is necessary if symptoms appear.

  • Involuntary Muscle Movements: Promethazine might cause uncontrollable muscle movements, particularly if taken with MAOIs or in sick, dehydrated children. Consult a healthcare provider if these symptoms develop.

Promethazine should not be used in certain cases, including in children under 2, individuals in a coma, those with lower respiratory tract issues such as asthma, those allergic to phenothiazines, or when an injection is administered into an artery or under the skin. Always consult a healthcare provider to ensure safe use of promethazine.

Promethazine Side Effects

Common side effects:

  • drowsiness
  • dizziness
  • dry mouth
  • constipation
  • blurred vision

Less common but important to monitor:

  • persistent sore throat
  • fever
  • chills
  • loss of coordination
  • fainting
  • hallucinations
  • restlessness
  • trouble urinating
  • slow heartbeat
  • unusual body movements
  • easy bruising
  • severe stomach pain
  • yellowing of the eyes or skin

Serious side effects:

  • neuroleptic malignant syndrome (NMS)
  • severe allergic reaction

Promethazine Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Interactions with low risk that usually do not require a change in therapy:

  • Aminolevulinic Acid
  • Belladonna
  • Belladonna Alkaloids
  • Betel Nut
  • Evening Primrose
  • Midodrine
  • Phenylalanine
Promethazine FAQs
What is the drug promethazine used for?

Promethazine is used to treat allergy symptoms, such as itching, runny nose, and sneezing. It is also used to prevent motion sickness, treat nausea and vomiting, and as a sedative or sleep aid. Additionally, it may be used to enhance the effects of certain pain medications.

Promethazine and Zofran are not the same. Promethazine is an antihistamine used to treat allergy symptoms, nausea, and vomiting, while Zofran (ondansetron) is a selective serotonin 5-HT3 receptor antagonist used primarily to prevent nausea and vomiting caused by chemotherapy, radiation therapy, or surgery. They work differently and are used for different purposes.

It is generally not recommended to take Benadryl (diphenhydramine) and promethazine together without consulting a healthcare provider. Both medications are antihistamines and can cause increased sedation, drowsiness, and other side effects when combined. It is important to seek advice from a healthcare professional to ensure safe use.

For nausea, medications stronger than promethazine may include ondansetron (Zofran) or metoclopramide (Reglan). Ondansetron is often used for severe nausea, such as that associated with chemotherapy, while metoclopramide can be used for nausea related to gastrointestinal issues. It's important for individuals to consult with a healthcare provider to determine the most appropriate medication for their specific condition.

Doctors prescribe promethazine for several reasons, including to treat allergy symptoms, prevent motion sickness, alleviate nausea and vomiting, and as a sedative or sleep aid. It is also sometimes used to enhance the effects of certain pain medications.

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