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When using this medication, it is important to be aware of potential interactions and take necessary precautions to ensure safe use. Here are some key points to consider:

• Drug and Substance Interactions: Some products that could interact with this medication include topical antihistamines like diphenhydramine cream, ointment, or spray. Inform your healthcare provider if you are consuming other substances that may induce drowsiness. This includes opioid painkillers or cough suppressants (e.g., codeine, hydrocodone), alcohol, cannabis, sleep aids or anxiety medications (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), and additional antihistamines (e.g., cetirizine, diphenhydramine).

• Checking Medication Labels: Carefully review the labels on all your medications, including those for allergies or cough-and-cold remedies, as they might contain components that cause drowsiness. Consult your pharmacist to ensure safe use of these products.

• Laboratory Tests Interference: This drug may interfere with specific laboratory tests, such as allergy skin tests, potentially leading to inaccurate results. It is crucial to inform laboratory personnel and all your healthcare providers that you are using this medication.

By following these guidelines, you can help mitigate risks and ensure the safe and effective use of this medication.

Common side effects:

• Drowsiness
• Dizziness
• Headache
• Constipation
• Stomach upset
• Blurred vision
• Decreased coordination
• Dry mouth, nose, or throat

Serious side effects:

• Mental or mood changes like hallucinations
• Irritability
• Nervousness
• Confusion
• Ringing in the ears
• Trouble urinating
• Easy bruising or bleeding
• Fast or irregular heartbeat
• Seizures
• Severe allergic reactions like rash, itching, swelling, severe dizziness, or difficulty breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Opioid pain relievers or cough suppressants (e.g., codeine, hydrocodone)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Alcohol
• Marijuana (cannabis)
• Sleep or anxiety medications (e.g., Alprazolam, Lorazepam, Zolpidem)
• Muscle relaxants (e.g., Carisoprodol, Cyclobenzaprine)
• Other antihistamines (e.g., Cetirizine, diphenhydramine)

Interactions with low risk that usually do not require a change in therapy:

• Topical antihistamines like diphenhydramine cream, ointment, and spray