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Here are essential safety considerations and warnings for individuals using Diacomit (stiripentol). It is crucial to thoroughly review these points and discuss any concerns with your healthcare provider.

• Depression and Suicidal Thoughts: Diacomit may exacerbate depression and lead to suicidal thoughts or actions, particularly in individuals with a history of depression. Monitor for any unusual mood or behavioral changes and report them to your healthcare provider immediately.

• Drowsiness: This medication can induce sleepiness, potentially impairing your ability to concentrate, think, and react. Avoid engaging in tasks that require full alertness, such as driving or operating heavy machinery, until you understand how Diacomit affects you. Alcohol consumption and medications that cause drowsiness, like opioids or benzodiazepines, can increase the risk of serious injury. Consult your healthcare provider if drowsiness persists or is problematic.

• Hematological Concerns: Diacomit can reduce white blood cell and platelet counts, which are crucial for immune response and blood clotting. Regular blood tests are necessary before beginning treatment and every six months thereafter. If you experience frequent illnesses, prolonged recovery times, or signs of bleeding (such as easy bruising or blood in your urine or stool), contact your healthcare provider promptly.

• Weight and Appetite Changes: Some individuals may experience decreased appetite, nausea, or vomiting, potentially leading to weight loss. Close monitoring of a child's growth is advised while on Diacomit. Report any significant weight changes to your healthcare provider.

• Phenylalanine Risk: The powder form of Diacomit contains phenylalanine, which is harmful to people with phenylketonuria (PKU). High phenylalanine levels can result in seizures, developmental delays, and behavioral issues. If you or your child has PKU, discuss the potential risks and benefits with your healthcare provider before starting treatment.

• Withdrawal Symptoms: Abrupt cessation of Diacomit can lead to withdrawal symptoms, including increased frequency and duration of seizures. To minimize this risk, consult your healthcare provider for guidance on gradually discontinuing the medication.

These precautions ensure safe use of Diacomit, and open communication with your healthcare provider is crucial for managing any side effects or concerns.

When taking this medication, some individuals may experience common side effects such as dizziness, drowsiness, nausea, decreased appetite, weight loss, and trouble sleeping. These effects are generally mild and often resolve on their own. However, if they persist or worsen, it is advisable to consult a healthcare provider for guidance and reassurance.

Less frequently, users may encounter issues such as vomiting, fatigue, increased saliva production, fever, bronchitis, cold symptoms, balance or coordination problems, agitation, weak muscle tone, tremor, slurred speech, and weight gain. If these occur and are troublesome, speaking with a healthcare provider is recommended to manage these symptoms effectively.

Serious side effects, although rare, require immediate medical attention. These include symptoms of low white blood cells, such as repeated fevers and infections, and low platelets, which can lead to prolonged bleeding, easy bruising, and blood in urine or stool. Additionally, mood changes like depression, suicidal thoughts, or aggression, as well as a severe allergic reaction characterized by rash, itching/swelling, severe dizziness, or trouble breathing, necessitate urgent medical care.

A small number of people taking anticonvulsants may experience significant mental health changes, including suicidal thoughts or attempts. It is crucial to monitor for any sudden mood or behavioral changes and seek medical help promptly if they arise. Always inform a healthcare provider about any side effects not listed to ensure comprehensive care.