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Carbamazepine use may lead to rare but severe skin reactions, which can be life-threatening. Individuals of specific ethnic backgrounds, particularly those of Asian or South Asian descent, may face a higher risk. Before starting the medication, your doctor may recommend a blood test to evaluate your risk level. If the test indicates an increased risk, your doctor will discuss the potential risks and benefits of carbamazepine as well as alternative treatments.

Skin reactions typically occur within the first few months of therapy. Seek immediate medical attention if you experience symptoms such as a rash, blisters, peeling skin, itching, or swelling. For further information, consult your doctor or pharmacist.

In rare cases, carbamazepine may also cause serious blood disorders, such as aplastic anemia or agranulocytosis. Your doctor will regularly monitor your blood counts to reduce the likelihood of these side effects. It is crucial to attend all scheduled medical and laboratory appointments. Immediate medical intervention is necessary if you experience symptoms like persistent sore throat, fever, swollen lymph nodes, unusual weakness or fatigue, shortness of breath, or easy bruising or bleeding.

Experiencing nausea, vomiting, dizziness, drowsiness, constipation, dry mouth, or a sense of unsteadiness is possible with this medication. These are generally mild effects, but if they persist or worsen, it's important to inform your healthcare provider. You might notice an empty tablet shell in your stool, which is harmless as the medication has been absorbed.

While this medication is beneficial for many, some serious side effects can occur. Immediately report severe or persistent headaches, liver issues (persistent nausea/vomiting, loss of appetite, abdominal pain, yellowing of the skin/eyes, dark urine), or kidney problems (changes in urine output). Seek prompt advice if you experience mouth sores, fainting, irregular heartbeat, unusual eye movements, vision changes, joint pain, swelling in the limbs, or numbness/tingling in extremities. Also, be vigilant for symptoms of low sodium levels like severe drowsiness, mental/mood changes, or seizures.

A small number of people on anticonvulsants may face mental health changes such as depression or suicidal thoughts. If any sudden behavioral changes occur, contact your healthcare provider immediately. Severe allergic reactions are rare but require urgent medical attention if symptoms like rash, swelling, severe dizziness, or breathing difficulties arise.

This summary doesn't cover all potential side effects. If you notice any unusual symptoms, reach out to your healthcare provider for guidance.

Some drugs that could interact with this medication include certain antifungal agents like isavuconazonium and Voriconazole, and the weight loss drug Orlistat. It's crucial to avoid combining this medication with MAO inhibitors, as this can lead to a dangerous, potentially fatal interaction. MAO inhibitors such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, and Tranylcypromine should not be taken during or for two weeks before starting this medication. Consult your doctor for guidance on when to begin or discontinue its use.

Other medications might alter how carbamazepine is processed in your body, impacting its effectiveness. This includes macrolide antibiotics like Erythromycin, rifamycins such as Rifabutin, and herbal products like St. John's wort. Conversely, carbamazepine can hasten the elimination of other drugs, affecting their function. This pertains to medications like artemether/lumefantrine, certain anticoagulants such as apixaban and Rivaroxaban, specific calcium channel blockers like Nifedipine and Nimodipine, Nefazodone, nirmatrelvir, certain HIV medications like Efavirenz, Etravirine, rilpivirine, Praziquantel, and ranolazine.

Additionally, this medication might reduce the effectiveness of hormonal birth control methods, including pills, patches, or rings, potentially leading to pregnancy. Discuss alternative birth control options with your healthcare provider, and report any new spotting or breakthrough bleeding, as these could indicate that your birth control is less effective.

Inform your doctor or pharmacist if you are using any products that cause drowsiness, such as alcohol, marijuana, antihistamines like Cetirizine and diphenhydramine, sleep or anxiety medications like Alprazolam, Diazepam, Zolpidem, muscle relaxants such as Carisoprodol and Cyclobenzaprine, and opioid painkillers like codeine and hydrocodone. Review the labels on your medications, including allergy or cold remedies, as they may contain ingredients that induce drowsiness. Your pharmacist can advise you on the safe use of these products.

Finally, this medication may interfere with certain laboratory tests, such as those for thyroid function or some pregnancy tests, potentially causing incorrect results. Ensure all healthcare providers and lab personnel are aware that you are taking this drug.