HomeDrug ClassesGliptin / Biguanide Combinations

Gliptin / Biguanide Combinations: Uses, Common Brands, and Safety Info

Gliptin/Biguanide combinations are drugs used for Type 2 diabetes, including brands such as Janumet and Jentadueto. Common side effects are gastrointestinal symptoms, and rare side effects include lactic acidosis. Regular blood sugar monitoring is necessary for optimal management.


Gliptin/Biguanide combinations, also known as DPP-4 inhibitors/Biguanide combinations, are a class of drugs used for the management of Type 2 diabetes mellitus. These medications are typically prescribed when diet and exercise alone do not sufficiently control blood sugar levels.

Common Brands

Some commonly prescribed gliptin/biguanide combination drugs include Janumet, Janumet XR, Jentadueto, and Komboglyze. These medications contain a dipeptidyl peptidase-4 (DPP-4) inhibitor, also known as a gliptin, and metformin, a type of biguanide.


Gliptin/biguanide combinations are generally safe and well-tolerated when taken as directed. However, as with any medication, there are potential side effects and precautions to consider. Common side effects of gliptin/biguanide combinations may include gastrointestinal symptoms such as nausea, diarrhea, and abdominal discomfort. In rare cases, these medications can cause a serious condition known as lactic acidosis, which is a buildup of lactic acid in the blood. Symptoms of lactic acidosis may include muscle pain, weakness, difficulty breathing, dizziness, and an irregular heartbeat. It is important to seek medical attention immediately if any of these symptoms occur. Gliptin/biguanide combinations may not be suitable for everyone. It is important to inform your healthcare provider about any pre-existing medical conditions, such as kidney or liver problems, and any medications you are currently taking before starting this class of drugs. As with all diabetes medications, regular blood sugar monitoring is essential to ensure proper glycemic control and to adjust the dosage if necessary.


Gliptin/biguanide combinations are a class of drugs used to manage Type 2 diabetes when diet and exercise alone are not sufficient. Commonly prescribed brands include Janumet, Janumet XR, Jentadueto, and Komboglyze. While generally safe and well-tolerated, potential side effects may include gastrointestinal symptoms and, rarely, lactic acidosis. Individuals with pre-existing medical conditions should consult their healthcare provider before starting this medication. Regular blood sugar monitoring is essential for optimal management of diabetes.