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This medication requires careful consideration of potential risks and precautions to ensure safe usage. Below are important safety warnings and guidelines for those taking this medication:

• Lactic Acidosis: Metformin, an ingredient in this medication, can lead to a rare but severe condition called lactic acidosis. This risk is heightened in individuals over 65, or those with kidney or liver disease, heart failure, heavy alcohol use, dehydration, or during certain medical procedures involving iodinated contrast. If you experience symptoms like unusual tiredness, dizziness, severe drowsiness, chills, blue/cold skin, muscle pain, rapid or difficult breathing, slow/irregular heartbeat, or stomach pain with nausea/vomiting/diarrhea, stop the medication and seek medical attention immediately.

• Pancreatitis: Some patients taking alogliptin have experienced pancreas inflammation. If you have a history of pancreatitis, discuss with your doctor before starting this medication.

• Heart Failure Risk: Alogliptin may increase the risk of heart failure, particularly for those with existing heart conditions or recent heart-related events. Discuss with your healthcare provider if you are at risk.

• Allergic Reactions: There is a possibility of severe allergic reactions, including rash, skin peeling, swelling, difficulty breathing, or anaphylaxis. Discontinue use and seek immediate medical help if these occur.

• Liver Problems: Alogliptin has been associated with abnormal liver function tests and potential liver damage. Regular monitoring may be necessary.

• Vitamin B12 Deficiency: Long-term use of metformin can affect vitamin B12 absorption, leading to deficiency and anemia. Ensure you have adequate dietary intake or supplementation.

• Hypoglycemia: When combined with other diabetes medications like insulin, this medication can cause dangerously low blood sugar levels. Monitor blood sugar closely and consult your provider about adjusting your treatment plan.

• Joint Pain: Severe joint pain has been reported with medications similar to alogliptin. If you experience joint discomfort, contact your healthcare provider.

• Severe Skin Reactions: Some have experienced a rash called bullous pemphigoid. Discontinue the medication and seek treatment if this occurs.

Contraindications: This medication should not be used by individuals with severe kidney problems or those with conditions leading to high acid levels in the body, such as diabetic ketoacidosis. If these apply to you, consult your healthcare provider for alternatives.

Always consult your healthcare provider to discuss these risks and determine if this medication is suitable for your condition.

When taking this medication, you may encounter some common side effects, which are usually mild and manageable. These include nausea, vomiting, stomach upset, diarrhea, bloating, gas, and weakness. You might also experience upper respiratory tract infections, cold symptoms like cough or runny nose, headaches, back pain, higher blood pressure, or urinary tract infections. If any of these symptoms persist or worsen, consult your healthcare provider for guidance.

It's important to be aware of more serious side effects that, while rare, require immediate medical attention. These include signs of lactic acidosis, such as confusion, weakness, fast heartbeat, rapid breathing, and loss of appetite. Pancreatitis symptoms like severe stomach pain, nausea, and vomiting need urgent care. Additionally, liver problems may manifest as tiredness, unexplained weight loss, dark urine, and yellowing of the skin or eyes. Severe allergic reactions, though uncommon, are also critical and may present as rash, blisters, swelling, or trouble breathing.

Low blood sugar is another potential side effect, particularly if this medication is used with other diabetes drugs. Symptoms include sudden sweating, shaking, hunger, blurred vision, and dizziness. To prevent low blood sugar, maintain a regular eating schedule and consult your healthcare provider if a meal is missed. Conversely, high blood sugar symptoms like increased thirst and urination should prompt a discussion with your provider to possibly adjust your treatment plan.

While these are primary side effects to monitor, any unusual symptoms should be reported to your healthcare professional to ensure safety and effective management of your health condition.

When taking Kazano (alogliptin/metformin), it's crucial to be aware of potential interactions with other medications. Inform your doctor and pharmacist about all the medications and supplements you use, which include prescriptions, over-the-counter drugs, vitamins, and herbal products.

Beta-blockers, such as metoprolol, propranolol, and timolol (used in some glaucoma eye drops), can mask the rapid heartbeat typically associated with low blood sugar (hypoglycemia). However, they do not affect other low blood sugar symptoms like dizziness, hunger, or sweating. Since many drugs can influence blood sugar levels, managing them can be challenging. Always discuss with your healthcare provider before starting, stopping, or adjusting any medication. Regular blood sugar monitoring is essential, and you should report any signs of high or low blood sugar to your doctor, who may adjust your diabetes treatment plan accordingly.

Kazano may also interact with various other medications. It is generally advised to avoid using Kazano with certain drugs, including specific contrast agents used in imaging tests. Sometimes, Kazano can be combined with other medications, but your doctor might need to adjust the dosage or usage frequency. Some interactions may increase the risk of side effects, but the combination might be necessary for optimal treatment. Therefore, continuous communication with your healthcare provider is vital in managing these interactions safely.