HomeDrug ClassesMineralocorticoid Receptor Antagonists

Mineralocorticoid Receptor Antagonists: Uses, Common Brands, and Safety Info

Mineralocorticoid Receptor Antagonists (MRAs) are medications used to treat conditions related to excessive aldosterone activity. They work by blocking the action of aldosterone, helping to reduce sodium retention and increase urinary excretion. MRAs are commonly used for hypertension, heart failure, and kidney disorders. Common brands include Spironolactone, Eplerenone, Amiloride, and Triamterene. However, they may have side effects such as hyperkalemia


Mineralocorticoid Receptor Antagonists (MRAs) are a class of medications primarily used for the treatment of conditions related to excessive aldosterone activity. Aldosterone is a hormone produced by the adrenal glands responsible for regulating the balance of water and electrolytes in the body. MRAs work by blocking the action of aldosterone at the mineralocorticoid receptors in various tissues, leading to a decrease in sodium retention and an increase in urinary excretion of both sodium and water. This class of drugs is commonly prescribed to manage hypertension, heart failure, and certain kidney disorders.


MRAs have several important clinical uses: 1. Hypertension: MRAs such as spironolactone and eplerenone are often prescribed as adjunct therapy in the management of essential hypertension. By reducing sodium levels in the body, these medications help to lower blood pressure levels. 2. Heart Failure: MRAs have proven to be beneficial in the treatment of heart failure with reduced ejection fraction (HFrEF). They can improve symptoms, reduce hospitalizations, and decrease mortality rates in patients with this condition. 3. Edema: These medications can be used to alleviate fluid retention (edema) associated with certain cardiac and renal disorders. By modulating aldosterone activity, they promote diuresis and help to reduce swelling. 4. Primary Aldosteronism: MRAs are utilized in the management of primary aldosteronism, a condition characterized by excessive aldosterone production by the adrenal glands. Treating this condition with MRAs can help to normalize blood pressure and electrolyte imbalances.

Common Brands

There are several branded and generic MRAs available on the market. Some commonly prescribed medications in this class include: - Spironolactone (Aldactone) - Eplerenone (Inspra) - Amiloride (Midamor) - Triamterene (Dyrenium) It's important to note that availability may vary based on location and healthcare system.


Like any medication, MRAs come with their own set of potential side effects and considerations. It is crucial to discuss the risks and benefits with a healthcare professional before starting treatment. Some common safety points include: 1. Hyperkalemia: MRAs can lead to higher levels of potassium in the blood. Regular monitoring of potassium levels is necessary, especially in patients with kidney disease or those taking other potassium-sparing medications. 2. Gynecomastia: Spironolactone, in particular, can cause breast tissue enlargement in males. This side effect is usually dose-dependent and reversible upon discontinuation of the medication. 3. Drug interactions: MRAs can interact with other medications, including certain blood pressure-lowering drugs and nonsteroidal anti-inflammatory drugs (NSAIDs). It is important to inform healthcare providers about all medications being taken to avoid potential interactions. 4. Pregnancy and lactation: Some MRAs may be contraindicated during pregnancy and breastfeeding due to potential risks to the fetus or infant. It is vital to consult a healthcare professional for guidance if planning to conceive or if already pregnant or nursing. Always follow the prescribed dosage and instructions provided by the healthcare professional. If any adverse effects or concerns arise, it is important to promptly inform the prescribing doctor.

List of Mineralocorticoid Receptor Antagonists