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The following safety information highlights important warnings and precautions associated with the use of Spironolactone (Aldactone). Please review these details carefully, and consult your healthcare provider if you have any questions or concerns.

• High Blood Potassium Levels: Spironolactone (Aldactone) can increase potassium levels in your blood, which can become a serious concern. This risk is elevated for individuals with kidney issues or those taking other medications that also raise potassium levels. Your healthcare provider will monitor your potassium levels a week after starting the medication and regularly thereafter to ensure they remain within a safe range. If your potassium levels become too high, your provider may adjust your dosage or discontinue the medication. Symptoms of high potassium levels include fatigue, muscle weakness, numbness, nausea, or vomiting. Risk factors include kidney problems, diabetes, and the use of potassium-based salt substitutes.

• Low Blood Pressure and Kidney Issues: Because Spironolactone (Aldactone) increases urination, it may lead to dehydration, low blood pressure, and potential kidney issues. This risk is greater for those with pre-existing kidney problems or who are taking other medications that can affect kidney function, such as NSAIDs or certain antibiotics. Regular blood tests may be ordered by your provider to monitor kidney health while on this medication.

• Imbalanced Electrolytes: The use of Spironolactone (Aldactone) can result in lower sodium, calcium, and magnesium levels in the blood, which are critical for various bodily functions. Imbalances may lead to symptoms like muscle cramps, fainting, irregular heartbeats, or seizures. Your healthcare provider will regularly check these electrolyte levels to ensure ongoing safety.

• Breast Pain or Swelling: This medication may cause breast tenderness or swelling in both males and females, particularly at higher doses. This side effect can occur within the first couple of months or after prolonged use. Symptoms usually resolve upon discontinuation of the drug. If you find this side effect bothersome, consult your healthcare provider for alternative treatment options.

Contraindications: Do not use Spironolactone (Aldactone) if you have any of the following conditions, as it may pose serious health risks:

• High potassium levels
• Addison's disease
• Concurrent use with eplerenone (Inspra)

Always discuss your health conditions and any medications you are taking with your healthcare provider to ensure Spironolactone (Aldactone) is safe for you.

Spironolactone can result in a range of side effects, but many of them are mild and manageable. Commonly experienced side effects include dizziness, drowsiness, headache, nausea, vomiting, diarrhea, stomach upset, and lightheadedness. If you notice any of these symptoms persisting or worsening, it is advisable to consult a healthcare provider. To prevent dizziness and lightheadedness, it is recommended to rise slowly from sitting or lying positions.

Some side effects, though less common, may require more immediate attention. These include muscle cramps, breast pain or enlargement in men, changes in menstrual periods, and lower sexual drive or sexual dysfunction. It's important to monitor for signs of dehydration or electrolyte imbalances such as unusual dry mouth, muscle weakness, irregular heartbeat, or confusion, and report these to a healthcare provider promptly.

Severe side effects are rare but demand urgent medical attention. These include symptoms of kidney issues like a decrease in urine, severe allergic reactions such as rash and trouble breathing, or signs of liver problems like persistent nausea, dark urine, and yellowing of the skin or eyes. Additionally, be alert for symptoms indicating high potassium levels, such as muscle weakness and a racing heart, or serious skin reactions like blistering or peeling. If you experience any new or concerning symptoms, it is crucial to seek medical advice.

Spironolactone (Aldactone) can interact with various medications and products. It is important to inform your doctor and pharmacist about all medications and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products.

Interactions to Avoid:

• Eplerenone and Triamterene: It is generally advisable not to use these medications with Spironolactone, as they may lead to serious interactions.

Use with Caution:

• Medications Increasing Potassium Levels: Drugs such as Amiloride, Cyclosporine, eplerenone, Tacrolimus, triamterene, and birth control pills containing drospirenone can increase potassium levels, which may be harmful when combined with Spironolactone.
• NSAIDs and Blood Pressure Medicines: Nonsteroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen or Naproxen, as well as certain blood pressure medications, may raise blood pressure or worsen swelling. Consult your pharmacist for safe usage.
• Other Medications and Supplements: Aspirin, Lithium, Digoxin, and many others may require dose adjustments or monitoring when taken with Spironolactone due to potential side effects or interactions.

Monitoring Recommendations:

• Lab Tests: Spironolactone may affect the results of certain lab tests, such as digoxin or cortisol levels. Ensure that your healthcare providers are aware you are taking Spironolactone to avoid misleading test results.

By keeping healthcare professionals informed and following their advice on medication adjustments, you can minimize the risks of drug interactions while using Spironolactone.