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This safety information provides crucial details about the potential risks and necessary precautions associated with the use of this medication. Please read thoroughly and discuss any concerns with your healthcare provider.

• Risk of High Potassium Levels (Hyperkalemia): The use of Eplerenone (Inspra) may lead to elevated potassium levels in the blood, which can be dangerous. Extremely high potassium levels can affect heart rhythm and, in severe cases, lead to cardiac arrest. Individuals with existing kidney issues, diabetes, or those taking medications such as ACE inhibitors, ARBs, and NSAIDs are at an increased risk. Be vigilant for symptoms like sudden numbness, tingling, nausea, or muscle weakness. Contact your healthcare provider immediately if these occur, as they may need to adjust your dosage.

• Contraindications: This medication is not suitable for everyone. It should be avoided by individuals with:

  • Critically high potassium levels.
  • Severe kidney issues.
  • Concurrent use of specific medications, including ketoconazole, ritonavir (Norvir), or clarithromycin.

• Specific Conditions:

  • For individuals with high blood pressure, avoid using this medication if you have type 2 diabetes with significant protein in the urine (microalbuminuria), moderate to severe kidney problems, or are using potassium supplements or potassium-sparing diuretics such as spironolactone (Aldactone), amiloride (Midamor), or triamterene (Dyrenium).

These guidelines are in place to ensure your safety while using this medication. Always consult your healthcare provider for personalized advice and before making any changes to your medication regimen.

When taking this medication, some common side effects may include headache, dizziness, digestive system issues, urinary tract problems, and shortness of breath. These are generally mild, but if they persist or worsen, it's important to contact your healthcare provider for advice. Some individuals may also experience skin issues, mental health changes, or a cough.

More serious side effects, though less common, should be addressed promptly. These include abnormal vaginal bleeding, enlargement or soreness of breasts in males, and symptoms associated with high potassium levels, such as muscle weakness and irregular heartbeat. Immediate medical attention is necessary for severe symptoms like chest pain or a heart attack.

While a severe allergic reaction is rare, be vigilant for symptoms such as rash, severe dizziness, or trouble breathing, and seek emergency medical help if these occur. Always communicate any unusual or severe side effects to your healthcare provider to ensure your safety and well-being.

When taking Eplerenone (Inspra), it's important to be aware of potential interactions with other medications or supplements. Inform your healthcare provider about all the drugs and supplements you are currently using, including prescription, over-the-counter, vitamins, and herbal products.

Certain medications like those that increase potassium levels in the blood, such as birth control pills with drospirenone and potassium-sparing diuretics (e.g., amiloride, spironolactone, triamterene), may interact with Eplerenone. Additionally, lithium can also interact with this medication.

Some drugs can influence how Eplerenone is eliminated from your body, potentially altering its effectiveness. These include adagrasib, azole antifungals like ketoconazole and itraconazole, clarithromycin, cobicistat, nefazodone, certain HIV protease inhibitors like nelfinavir and ritonavir, and herbal supplements such as St. John's wort.

Moreover, certain products, especially those used for cough and cold, diet aids, or NSAIDs like ibuprofen and naproxen, may increase blood pressure or worsen heart failure. It’s crucial to discuss any such products with your pharmacist to ensure safe usage.

In some cases, using Eplerenone with other medications might not be advised or might require dose adjustments, such as with aceclofenac, aspirin, celecoxib, fluconazole, and many others. These interactions might increase side effects or affect treatment efficacy, so your healthcare provider may need to adjust dosages or monitor your treatment closely.