HomeDrug ClassesOpioid / Anticholinergic Combinations

Opioid / Anticholinergic Combinations: Uses, Common Brands, and Safety Info

Opioid / Anticholinergic combinations are medications used to manage moderate to severe pain. They work by binding to opioid receptors and include anticholinergic drugs to address side effects. Common brands include Hycodan, Oxytrol, and Skopel. Safety precautions include following prescribed dosage, discussing current medications with a healthcare professional, and monitoring for side effects. Consulting a healthcare professional is necessary before discontinuing use. Overall, these medications provide effective pain management when used cautiously.

Drug Class: Opioid / Anticholinergic Combinations

Opioid / Anticholinergic combinations are a class of medications that consist of the combination of an opioid drug and an anticholinergic drug. These medications are primarily used for the management of moderate to severe pain.


Opioid / Anticholinergic combinations are typically prescribed to provide relief from pain that is not adequately controlled by other pain medications. They are commonly used in postoperative settings, for cancer-related pain, and in chronic pain conditions such as osteoarthritis or fibromyalgia.

These medications work by binding to opioid receptors in the brain and spinal cord, inhibiting the transmission of pain signals. Anticholinergic drugs are included in the combination to help alleviate some of the side effects of opioids, such as nausea, vomiting, and constipation.

Common Brands

Some commonly prescribed opioid / anticholinergic combinations include:

  • Hydrocodone and Homatropine - brand name Hycodan

  • Oxycodone and Atropine - brand name Oxytrol

  • Morphine and Scopolamine - brand name Skopel


While opioid / anticholinergic combinations can be effective in managing pain, it is essential to use them with caution due to the potential for side effects and the risk of opioid dependence or addiction. It is important to take these medications only as prescribed by a healthcare professional and to closely monitor their use.

Patient safety can be enhanced by discussing any current medications, including over-the-counter drugs and herbal supplements, with the prescribing doctor to minimize the risk of drug interactions. It is important to notify the healthcare provider immediately if any unusual or severe side effects occur while taking these medications.

Additionally, these medications should not be abruptly discontinued without consulting a healthcare professional, as it may lead to withdrawal symptoms. Opioid / anticholinergic combinations require careful monitoring and periodic evaluation of their efficacy and safety to ensure appropriate pain management.

In summary, opioid / anticholinergic combinations are a class of medications used for moderate to severe pain management. They work by binding to opioid receptors, reducing pain signals, and are often combined with anticholinergic drugs to alleviate common opioid side effects. It is crucial to use these medications safely, under the guidance of a healthcare professional, and to monitor their use for optimal pain relief while minimizing risks.

List of Opioid / Anticholinergic Combinations