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This medication carries a potential for misuse and dependency, which could result in overdose and possibly be fatal. It may also induce serious, potentially life-threatening breathing issues. To minimize these risks, your healthcare provider should prescribe the lowest effective dose for the shortest duration necessary.

• The likelihood of severe respiratory problems is greater at the onset of treatment, or if the prescribed dose is exceeded.
• Combining this medication with alcohol or other substances that induce drowsiness or respiratory issues can lead to critical side effects, including death.
• Some medications may interfere with the elimination of this drug from your system, impacting its effectiveness. Ensure you understand the correct usage and which medications to avoid.

Immediate medical attention is crucial if you experience any of the following severe symptoms: slow or shallow breathing, unusual lightheadedness, extreme drowsiness or dizziness, or difficulty waking up.

• Store this medication securely to prevent theft, misuse, or abuse. Seek urgent medical assistance if someone accidentally ingests the drug.

Before starting this medication, women of childbearing potential should discuss potential risks and benefits with their healthcare provider. Inform your doctor if you are pregnant or suspect you might be. Use during pregnancy, particularly in the first two months, is not advised as it might slightly increase the risk of birth defects. Prolonged or high-dose use near the time of delivery may harm the unborn child. To minimize risks, adhere to the lowest effective dose for the shortest duration.

Newborns exposed to this medication for extended periods may experience serious (potentially fatal) withdrawal symptoms. Contact a healthcare provider immediately if your newborn exhibits signs such as persistent crying, slow or shallow breathing, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight.

Hydrocodone can cause nausea, especially during the initial doses, but it often subsides with time. To alleviate nausea, consider taking it with food and resting with minimal head movement for a short while. Other common side effects include lightheadedness, dizziness, drowsiness, vomiting, and constipation. If these persist or worsen, it's important to consult with a healthcare professional. To manage constipation, incorporate dietary fiber, stay hydrated, and engage in regular exercise. A pharmacist can advise on suitable laxatives if needed. Reducing the risk of dizziness and lightheadedness can be achieved by rising slowly from sitting or lying positions.

While many users experience no severe side effects, be vigilant for signs such as sleep apnea, abdominal pain, or mood changes like agitation or confusion, and report these to a medical professional immediately. In rare cases, serious side effects like eye pain, vision changes, irregular breathing, severe drowsiness, seizures, or fainting may occur, requiring urgent medical attention. Although allergic reactions are rare, symptoms like rash, swelling, or severe dizziness should prompt immediate medical intervention.

This summary does not cover all possible side effects, so if you encounter any unlisted symptoms, reach out to a healthcare provider for guidance.

Certain medications can interact with this drug, including some pain relievers like Butorphanol, Nalbuphine, and pentazocine, as well as Naltrexone, potassium supplements, pramlintide, and samidorphan. Using this medication with other substances that cause drowsiness or breathing difficulties can heighten the risk of serious side effects, such as slow or shallow breathing and severe drowsiness or dizziness. Inform your healthcare provider if you're also using other opioid pain or cough medications (for example, codeine or Hydromorphone), alcohol, marijuana (cannabis), sleep or anxiety medications (such as Alprazolam, Lorazepam, or Zolpidem), muscle relaxants (like Carisoprodol or Cyclobenzaprine), or antihistamines (such as Cetirizine or diphenhydramine).

Be sure to review the labels of all your medications, including those for allergies or cough-and-cold, as they might contain ingredients that can cause drowsiness. Consult your pharmacist on how to use these products safely.

Additionally, some drugs may impact how your body processes hydrocodone/homatropine, potentially altering its effectiveness. These include azole antifungals (such as Ketoconazole), macrolide antibiotics (like Erythromycin), Mifepristone, certain HIV medications (such as tipranavir), rifamycins (like Rifabutin or Rifampin), Ritonavir, and some seizure medications (such as Carbamazepine or Phenytoin).

This medication might affect certain laboratory tests, such as amylase or lipase levels, potentially leading to inaccurate results. Ensure that your healthcare providers and lab technicians are aware that you are taking this medication.