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Hydrocodone can cause nausea, especially during the initial doses, but it often subsides with time. To alleviate nausea, consider taking it with food and resting with minimal head movement for a short while. Other common side effects include lightheadedness, dizziness, drowsiness, vomiting, and constipation. If these persist or worsen, it's important to consult with a healthcare professional. To manage constipation, incorporate dietary fiber, stay hydrated, and engage in regular exercise. A pharmacist can advise on suitable laxatives if needed. Reducing the risk of dizziness and lightheadedness can be achieved by rising slowly from sitting or lying positions.

While many users experience no severe side effects, be vigilant for signs such as sleep apnea, abdominal pain, or mood changes like agitation or confusion, and report these to a medical professional immediately. In rare cases, serious side effects like eye pain, vision changes, irregular breathing, severe drowsiness, seizures, or fainting may occur, requiring urgent medical attention. Although allergic reactions are rare, symptoms like rash, swelling, or severe dizziness should prompt immediate medical intervention.

This summary does not cover all possible side effects, so if you encounter any unlisted symptoms, reach out to a healthcare provider for guidance.

Certain medications can interact with this drug, including some pain relievers like Butorphanol, Nalbuphine, and pentazocine, as well as Naltrexone, potassium supplements, pramlintide, and samidorphan. Using this medication with other substances that cause drowsiness or breathing difficulties can heighten the risk of serious side effects, such as slow or shallow breathing and severe drowsiness or dizziness. Inform your healthcare provider if you're also using other opioid pain or cough medications (for example, codeine or Hydromorphone), alcohol, marijuana (cannabis), sleep or anxiety medications (such as Alprazolam, Lorazepam, or Zolpidem), muscle relaxants (like Carisoprodol or Cyclobenzaprine), or antihistamines (such as Cetirizine or diphenhydramine).

Be sure to review the labels of all your medications, including those for allergies or cough-and-cold, as they might contain ingredients that can cause drowsiness. Consult your pharmacist on how to use these products safely.

Additionally, some drugs may impact how your body processes hydrocodone/homatropine, potentially altering its effectiveness. These include azole antifungals (such as Ketoconazole), macrolide antibiotics (like Erythromycin), Mifepristone, certain HIV medications (such as tipranavir), rifamycins (like Rifabutin or Rifampin), Ritonavir, and some seizure medications (such as Carbamazepine or Phenytoin).

This medication might affect certain laboratory tests, such as amylase or lipase levels, potentially leading to inaccurate results. Ensure that your healthcare providers and lab technicians are aware that you are taking this medication.