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The safety information below outlines critical warnings and precautions regarding the use of chlorpheniramine/phenylephrine. Please review them thoroughly and consult your healthcare provider with any questions or concerns.

• Serotonin Syndrome Risk: This medication can increase serotonin levels in the brain, potentially leading to serotonin syndrome, a rare but serious condition. The risk is elevated if combined with other serotonin-altering drugs such as antidepressants, lithium, certain Parkinson's medications, or MAOIs, as well as excessive intake of chlorpheniramine/phenylephrine. Inform your healthcare provider about all medications and supplements you are taking to avoid interactions. Symptoms of serotonin syndrome include rapid heartbeat, sweating, muscle stiffness, fever, and confusion. Seek immediate medical attention if these symptoms occur.

• Driving and Alertness: Chlorpheniramine/phenylephrine may impair your concentration and reaction time. This effect is intensified by alcohol or other sedatives like benzodiazepines and opioids. Refrain from driving or operating heavy machinery until you know how the medication affects you.

• Exacerbation of Medical Conditions: This medication can worsen certain health issues. Discuss your full medical history with your healthcare provider, especially if you have conditions such as heart problems, high blood pressure, glaucoma, thyroid disorders, diabetes, respiratory issues, or urinary difficulties. Your provider will determine if this medication is suitable for you.

• Contraindications: Do not use chlorpheniramine/phenylephrine if you are currently taking or have recently taken an MAOI within the last 14 days, as this may lead to serious health risks. Always consult with your healthcare provider regarding any contraindications before starting this medication.

When taking this medication, some individuals may experience common side effects such as drowsiness, dizziness, dry mouth, headache, upset stomach, constipation, or trouble sleeping. These effects are generally mild, but if they persist or worsen, it's important to consult a healthcare provider. In children, excitability may also occur.

While many people do not experience serious side effects, there are some that require prompt medical attention. These include mental or mood changes such as confusion or hallucinations, ringing in the ears, difficulty urinating, and vision changes like blurred or double vision. If you encounter severe side effects such as a fast or irregular heartbeat or seizures, seek immediate medical help.

Rarely, a serious allergic reaction may occur, characterized by symptoms such as a rash, itching, swelling of the face, lips, tongue, or throat, severe dizziness, and trouble breathing. In such cases, it is crucial to get emergency medical assistance right away.

Additionally, serotonin syndrome, a serious condition marked by a fast heart rate, sweating, muscle stiffness, fever, and confusion, may occur and necessitates urgent care. Heart palpitations and increased blood pressure are also serious and require immediate attention. Always contact a healthcare professional if you notice any other unusual effects.

Some medications and substances can interact with this drug. It is important to avoid using skin-applied antihistamines, like diphenhydramine cream, ointment, or spray, while taking this medication. Additionally, combining MAO inhibitors with this drug can lead to severe and potentially life-threatening reactions. Do not use MAO inhibitors such as isocarboxazid, Linezolid, Metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, or Tranylcypromine while on this medication, and they should generally not be used for two weeks before starting this treatment. Consult your doctor for guidance on when to begin or discontinue these medications.

Inform your doctor or pharmacist if you're using other substances that cause drowsiness, including opioid pain or cough medications (like codeine or hydrocodone), alcohol, marijuana, sleep or anxiety drugs (such as Alprazolam, Lorazepam, or Zolpidem), muscle relaxants (like Carisoprodol or Cyclobenzaprine), or other antihistamines (such as Cetirizine or diphenhydramine).

Carefully check the labels of all your medicines, especially those for allergies or cough-and-cold, as they may contain ingredients that induce drowsiness. Your pharmacist can provide advice on their safe use. Furthermore, this medication might affect certain medical or laboratory tests, such as brain scans for Parkinson's disease, urine drug screenings, or allergy skin tests, possibly leading to inaccurate results. Ensure all healthcare providers and lab technicians are aware of your use of this medication.