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It's essential to be aware of the safety information and warnings associated with the use of Augmentin (amoxicillin/clavulanate). Below are key points to consider, which should be discussed with your healthcare provider if you have any concerns.

• Allergic Reactions: There is a risk of severe allergic responses, including potentially life-threatening reactions like facial swelling and anaphylaxis. If you have a history of allergies to antibiotics, particularly penicillin, or are currently experiencing a mononucleosis infection, inform your healthcare team to assess your risk.

• Liver Health: Rare cases of serious liver issues have been reported with Augmentin use. While these problems are usually reversible, they can be life-threatening. If you have a history of liver conditions, it's crucial to inform your healthcare provider, as monitoring through blood tests might be necessary.

• C. difficile Infection: The use of Augmentin can increase the risk of infection by Clostridioides difficile, a bacterium that can cause severe diarrhea due to the alteration of normal gut bacteria by antibiotics.

• Phenylketonuria (PKU) Caution: Chewable tablets and suspensions of Augmentin may contain phenylalanine, due to the presence of aspartame. This can be harmful if you have PKU, a genetic disorder, so ensure your healthcare provider is aware.

Contraindications: Do not use Augmentin if you have the following conditions, as it may cause significant health risks:

• A severe allergy to beta-lactam antibiotics, such as penicillin or cephalexin.
• A history of liver problems related to previous use of Augmentin.

Always consult your healthcare provider for personalized advice and guidance regarding medication use and potential risks.

Common side effects:

• diarrhea
• nausea
• skin rash

Less common but important to monitor:

• persistent nausea or vomiting
• loss of appetite
• stomach pain
• yellowing of the eyes or skin
• dark urine
• unusual tiredness
• easy bruising or bleeding
• oral thrush
• new yeast infection
• white patches in the mouth
• changes in vaginal discharge
• persistent fever
• lymph node swelling
• rash
• severe dizziness
• difficulty breathing

Serious side effects:

• rare but serious intestinal condition caused by C. difficile
• severe diarrhea
• abdominal cramping
• blood in the stool

Interactions with high risk of serious adverse effects and should be avoided:

• Methotrexate

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Chlortetracycline
• Cholera Vaccine, Live
• Desogestrel
• Dienogest
• Doxycycline
• Drospirenone
• Eravacycline
• Estradiol
• Ethinyl Estradiol
• Ethynodiol
• Gestodene
• Levonorgestrel
• Lymecycline
• Meclocycline
• Mestranol
• Methacycline
• Minocycline
• Mycophenolate Mofetil
• Nomegestrol
• Norethindrone
• Norgestimate
• Norgestrel
• Omadacycline
• Oxytetracycline
• Rolitetracycline
• Sarecycline
• Sulfasalazine
• Tetracycline
• Tigecycline
• Venlafaxine
• Warfarin

Interactions with low risk that usually do not require a change in therapy:

• Acenocoumarol
• Khat
• Probenecid