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When considering the use of Vaseretic (enalapril/hydrochlorothiazide), it is crucial to be aware of the following important safety information and warnings. This medication carries potential risks and requires certain precautions to ensure safe and effective use.

• Pregnancy Warning: Vaseretic should not be used during pregnancy, as enalapril can cause severe, potentially life-threatening harm to an unborn child. If you become pregnant while taking this medication, stop the medication immediately and inform your healthcare provider. Discuss alternative blood pressure treatments if you are pregnant or planning to become pregnant.

• Angioedema Risk: Enalapril may lead to angioedema, a rare but serious condition causing swelling in various body parts, including the face and tongue, which can impair breathing. This risk is heightened in individuals with a previous history of angioedema or in Black individuals. Seek emergency medical attention if you experience any swelling, stomach pain, or breathing difficulties.

• Allergic Reactions: Allergic reactions to Vaseretic can occur, especially in those with a history of allergies, asthma, or sulfa allergies. Symptoms may include rash, itching, hives, trouble breathing, or facial swelling. Notify your healthcare provider immediately if you notice these symptoms.

• Low Blood Pressure: This medication can cause significant drops in blood pressure, leading to dizziness, fatigue, or lightheadedness. This is more likely if you are dehydrated or have heart failure. Ensure adequate hydration, and seek medical help if you experience severe dizziness or a fall.

• Kidney and Liver Concerns: Vaseretic may impact kidney or liver function, particularly in individuals with pre-existing kidney problems, severe heart failure, or liver conditions. Regular blood tests may be necessary to monitor organ health. Report any decrease in urination or signs of liver issues such as fatigue or jaundice to your doctor.

• Electrolyte and Metabolic Changes: The medication can alter electrolyte balances, as well as blood sugar and cholesterol levels. Regular monitoring and reporting of symptoms like a fast heartbeat, weakness, or nausea are important.

• Vision Changes: Rare cases of vision changes or eye pain have been reported shortly after starting hydrochlorothiazide. Discontinue the medication and contact your healthcare provider if vision changes occur.

• Lupus Activation: In rare instances, Vaseretic can exacerbate or trigger lupus symptoms. Report any new or worsening symptoms to your healthcare provider.

• Contraindications: Avoid using Vaseretic if you have diabetes and are taking aliskiren, or if you have recently used neprilysin inhibitors. It should also not be used if you are unable to produce urine, or have allergies to sulfa medications or ACE inhibitors.

In case of overdose or adverse reactions, seek immediate medical assistance. Always consult with your healthcare provider for any concerns or questions about this medication.

Common side effects:

• Dizziness
• Lightheadedness
• Tiredness
• Headaches
• Dry cough

Less common but important to monitor:

• Muscle cramps
• Nausea
• Diarrhea
• Feelings of weakness
• Difficulty with erections

Serious side effects:

• Severe swelling (angioedema)
• Severe allergic reactions
• Dangerously low blood pressure
• Serious kidney issues
• Liver problems
• Pancreatitis

Interactions with high risk of serious adverse effects and should be avoided:

• Aliskiren
• Dofetilide
• Sacubitril
• Bee/wasp sting allergy desensitization injections

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aceclofenac
• Lithium
• Everolimus
• Sirolimus
• NSAIDs (e.g., Ibuprofen, Naproxen)
• Potassium-increasing medications