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The safety and warning information for Vaseretic (enalapril / hydrochlorothiazide) is crucial for ensuring safe usage. Please review the following details carefully and discuss any concerns with your healthcare provider:

• Pregnancy Warning: Vaseretic should not be used during pregnancy as it can cause severe harm to an unborn baby. If you become pregnant while taking this medication, or if you are planning to become pregnant, contact your healthcare provider immediately to discuss alternative treatments.

• Angioedema Risk: The enalapril component in Vaseretic may cause angioedema, a potentially life-threatening condition characterized by swelling of the face, tongue, or other body parts, and can affect breathing. Black individuals and those with a history of angioedema are at higher risk. Seek urgent medical attention if you experience any swelling or breathing difficulties.

• Allergic Reactions: Allergic reactions, including rashes, hives, or breathing difficulties, can occur, especially in individuals with a history of allergies, asthma, or sulfa allergies. Report any signs of an allergic reaction to your prescriber promptly.

• Low Blood Pressure: Vaseretic can cause blood pressure to drop excessively, leading to dizziness or lightheadedness. This is more likely if you are dehydrated or have heart failure. Ensure adequate hydration and report any severe dizziness or falls to your healthcare provider immediately.

• Kidney Health: Vaseretic may impact kidney function, particularly in individuals with pre-existing kidney issues or severe heart failure. Regular kidney function tests may be required, and any significant changes in urination should be reported to your prescriber.

• Liver Concerns: Rarely, Vaseretic can cause liver problems. Monitor for symptoms such as fatigue, abdominal pain, or yellowing of the skin, and inform your healthcare provider if these occur.

• Electrolyte and Metabolic Changes: The medication can alter electrolyte levels and affect blood sugar and cholesterol. Regular monitoring through blood tests is recommended. Report symptoms like rapid heartbeat, muscle pain, or significant changes in urination.

• Vision Issues: Some individuals may experience vision changes or eye pain shortly after starting Vaseretic. Notify your prescriber immediately, as untreated symptoms could lead to vision loss.

• Lupus: There is a rare risk of lupus exacerbation or development. Report any new rash or unusual fatigue to your prescriber.

Contraindications:

• Do not use Vaseretic if you have diabetes and are taking aliskiren (Tekturna), or if you're using neprilysin inhibitors like Entresto within 36 hours.
• Avoid if you have a history of angioedema, are allergic to sulfa medications or ACE inhibitors, or are unable to produce urine.

Always discuss any pre-existing conditions or concurrent medications with your healthcare provider before starting Vaseretic to ensure it is safe for you.

When taking this medication, some common side effects you might experience include dizziness, lightheadedness, headache, tiredness, and coughing. These effects are usually mild as your body adjusts to the medication. To reduce dizziness and lightheadedness, try standing up slowly from sitting or lying down. If these symptoms persist or become bothersome, it's advisable to consult your healthcare provider.

Less commonly, some people may experience muscle cramps, nausea, diarrhea, a sense of weakness, and difficulty maintaining an erection. Additionally, a sudden drop in blood pressure when standing can occur, which may cause dizziness or faintness. If you notice these effects, especially if they are severe, it's important to seek medical guidance.

There are rare but serious side effects that require immediate medical attention. These include symptoms of angioedema, such as severe swelling and pain in the stomach, nausea, vomiting, and swelling of the face or throat. Severe allergic reactions can manifest as swelling of the lips, tongue, or face, trouble breathing, and rash. Dangerously low blood pressure may present with pale skin, dizziness, and fainting, while serious kidney problems could involve reduced urination and swelling in extremities. Signs of liver issues, such as yellowing of the skin or eyes, stomach pain, and confusion, also warrant urgent care. Inflammation of the pancreas, indicated by stomach pain and a fast heartbeat, is another critical condition to watch for. If you experience any of these severe symptoms, seek medical help immediately.

Your safety and well-being are important, so keep an eye on how you feel and report any unusual or concerning symptoms to your healthcare provider promptly.

When taking Vaseretic (enalapril/hydrochlorothiazide), it's important to be aware of potential drug interactions. This medication should not be combined with certain drugs like aliskiren, dofetilide, and sacubitril, as these interactions can be harmful. Additionally, it can interact with medications that weaken the immune system, such as everolimus and sirolimus, as well as with lithium and drugs that raise potassium levels, like ARBs (e.g., losartan, valsartan) and birth control pills containing drospirenone.

A serious reaction might occur if you receive allergy shots for bee or wasp stings while taking this medication. Always inform your healthcare providers about all the medicines you use, including prescription, over-the-counter, and herbal products. Some medications and products can raise blood pressure or worsen heart failure, such as NSAIDs (e.g., ibuprofen, naproxen), cough-and-cold products, and diet aids. Consult your pharmacist about using these safely.

Vaseretic may also affect certain lab tests, leading to inaccurate results. Ensure that all your healthcare providers and lab personnel are aware that you are taking this medication.