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Etanercept is an immunosuppressant medication, which means it can diminish your body's defense against infections. Here are some important safety considerations and precautions to keep in mind:

• Infection Risk: The use of etanercept may increase your susceptibility to severe infections, including fungal and bacterial infections like tuberculosis. This medication can also worsen existing infections.
• Medical History: Inform your healthcare provider about any history of infections and if you have lived or traveled in areas known for specific fungal infections, such as coccidioidomycosis or histoplasmosis. These areas typically include the Ohio and Mississippi River valleys and the southwestern United States.
• Testing for Tuberculosis: You should undergo screening for tuberculosis (using a TB skin test or chest X-ray) prior to starting and during treatment with etanercept.
• Signs of Infection: Immediately report any signs of infection to your doctor, including persistent sore throat or cough, fever, chills, night sweats, painful or frequent urination, unusual vaginal discharge, or white patches in the mouth.
• Cancer Risk: Although rare, there is a slight risk of developing cancer, such as lymphoma or skin cancer, particularly in children, teenagers, and young adults. This risk may be associated with the medication or your underlying medical condition. Discuss the potential risks and benefits with your healthcare provider.
• Symptoms of Cancer: Contact your doctor promptly if you experience symptoms like a persistent fever, unusual lumps or growths, a swollen or painful abdomen, unexplained weight loss, or night sweats.

These precautions are crucial for ensuring your safety while using etanercept. Always consult with your healthcare provider for personalized medical advice.

When using this medication, you may experience some common side effects such as redness, itching, pain, or swelling at the injection site. These symptoms typically begin 1-2 days after the injection and usually resolve within 3-5 days. Over time, particularly after the first month, these reactions tend to decrease. A headache is another possible mild side effect. If these symptoms persist or worsen, consulting a healthcare professional is advisable.

While serious side effects are less common, it is important to be aware of them. These include signs of liver disease, such as persistent nausea or vomiting, dark urine, abdominal pain, and jaundice (yellowing of the eyes or skin). Other severe side effects may include the appearance of a butterfly rash on the face, dizziness, extreme fatigue, pallor, hair loss, swelling in the arms or legs, unusual bruising or bleeding, severe headaches, mood changes, seizures, unexplained muscle weakness, numbness or tingling in the extremities, balance issues, and vision changes.

Although very rare, a severe allergic reaction can occur. You should seek immediate medical attention if you experience symptoms like a rash, severe itching or swelling (especially of the face, tongue, or throat), dizziness, or difficulty breathing. If you encounter any other side effects not listed here, it is recommended to contact a healthcare provider for further advice.