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Azathioprine

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Azathioprine is used to prevent organ rejection in people who have received a kidney transplant. It is usually used along with other medications to allow your new kidney to function normally. Azathioprine is also used to treat rheumatoid arthritis. In this condition, the body's defense system (immune system) attacks healthy joints. Azathioprine belongs to a class of drugs known as immunosuppressants. It works by weakening the immune system to help your body accept the new kidney as if it were your own (in the case of an organ transplant) or to prevent further damage to your joints (in the case of rheumatoid arthritis). This medication is given by injection until you are able to take azathioprine by mouth. Talk to your doctor about the risks and benefits of azathioprine, especially when used by children and young adults.
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100MG, Azathioprine (30 Solution Reconstituteds)

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Warnings

Azathioprine may rarely increase your risk of developing certain types of cancer (such as lymphoma, skin cancer). This risk is higher in people using azathioprine after an organ transplant and in children/young adults being treated for certain bowel diseases (such as Crohn's disease, ulcerative colitis). Keep all medical and lab appointments. Tell your doctor right away if you develop any of the following symptoms: unusual skin changes, change in the appearance/size of moles, unusual growths/lumps, swollen lymph nodes, swollen abdomen, unexplained weight loss, night sweats. This medication may decrease bone marrow function, an effect that may lead to a low number of blood cells such as red cells, white cells, and platelets. This effect can cause anemia, decrease your body's ability to fight an infection, or cause easy bruising/bleeding. Tell your doctor right away if you develop any of the following symptoms: unusual tiredness, pale skin, signs of infection (such as sore throat that doesn't go away, fever, chills), easy bruising/bleeding.

Azathioprine Side Effects

Nausea or vomiting may occur. Taking this medication after meals may help lessen these effects. Temporary hair loss may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. People using this medication may have serious side effects. However, you have been prescribed this drug because your doctor has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk. Tell your doctor right away if you have any serious side effects, including: diarrhea, new or worsening joint/muscle pain. Get medical help right away if you have any very serious side effects, including: symptoms of liver disease (such as nausea/vomiting that doesn't stop, stomach/abdominal pain, dark urine, yellowing eyes/skin). This medication may increase your risk of getting a rare but very serious (possibly fatal) brain infection (progressive multifocal leukoencephalopathy-PML). Get medical help right away if you have any of these side effects: clumsiness, loss of coordination/balance, weakness, sudden change in your thinking (such as confusion, difficulty concentrating, memory loss), difficulty talking/walking, seizure, vision changes. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

Some products that may interact with this drug are: febuxostat, past or present use of certain cancer drugs (such as cyclophosphamide, melphalan), other drugs that weaken the immune system/increase the risk of infection (such as rituximab, tofacitinib). Azathioprine is very similar to mercaptopurine. Do not use medications containing mercaptopurine while using azathioprine.
Azathioprine FAQs
What is the drug azathioprine used for?

Azathioprine is used to suppress the immune system. It is commonly prescribed to prevent organ rejection in transplant patients and to treat autoimmune conditions such as rheumatoid arthritis, lupus, and inflammatory bowel diseases like Crohn's disease and ulcerative colitis.

Azathioprine is not commonly associated with weight gain as a side effect. However, individual responses to medication can vary. If there are concerns about weight changes while taking azathioprine, it is advisable to consult with a healthcare provider for personalized advice and evaluation.

Azathioprine is not classified as a traditional chemotherapy drug. It is an immunosuppressant medication primarily used to prevent organ transplant rejection and to treat autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease. While it does affect the immune system, its mechanism and use differ from those of conventional chemotherapy drugs used to treat cancer.

While taking azathioprine, one should avoid the following:1. Live Vaccines: Avoid receiving live vaccines, as azathioprine can weaken the immune system, making live vaccines potentially harmful.2. Sun Exposure: Limit exposure to sunlight or UV light, as azathioprine can increase sensitivity to the sun, raising the risk of skin cancer.3. Alcohol Consumption: Minimize alcohol intake, as both azathioprine and alcohol can affect liver function.4. Certain Medications: Avoid taking medications that can interact with azathioprine, such as allopurinol, without consulting a healthcare provider.5. Infection Risks: Be cautious of situations that increase the risk of infections, as azathioprine can lower the body's ability to fight infections.It is important to follow the healthcare provider's advice and report any unusual symptoms or concerns while on azathioprine.

Azathioprine is used to treat autoimmune conditions such as rheumatoid arthritis, lupus, and inflammatory bowel diseases like Crohn's disease and ulcerative colitis. It is also used to prevent organ rejection in transplant patients.

Azathioprine primarily affects the liver, as it is metabolized there. It can also impact the bone marrow, potentially leading to suppression of blood cell production. Regular monitoring of liver function and blood counts is recommended for individuals taking azathioprine.

Azathioprine is typically prescribed to help suppress the immune system. It is often used in the management of autoimmune conditions such as rheumatoid arthritis, lupus, and inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Additionally, it may be used to prevent organ rejection in transplant patients. The medication helps reduce immune system activity to prevent it from attacking the body's own tissues or a transplanted organ.

Azathioprine can potentially affect appetite as a side effect, although it is not one of the most common side effects. If a patient experiences significant changes in appetite or any other concerning symptoms while taking azathioprine, it is advisable to consult with a healthcare provider for further evaluation and management.

When taking azathioprine, it is generally advised to avoid foods that are high in purines, such as organ meats, certain fish, and shellfish, as they can increase uric acid levels and potentially exacerbate side effects. Additionally, it is important to avoid grapefruit and grapefruit juice, as they can interfere with the metabolism of the medication. It is always best to consult with a healthcare provider for personalized dietary recommendations while on azathioprine.

Azathioprine can have several disadvantages, including:1. Immunosuppression: It suppresses the immune system, increasing the risk of infections.2. Bone Marrow Suppression: It can lead to decreased production of blood cells, causing anemia, leukopenia, or thrombocytopenia.3. Gastrointestinal Issues: Nausea, vomiting, and diarrhea are common side effects.4. Liver Toxicity: It may cause liver damage, requiring regular monitoring of liver function.5. Increased Cancer Risk: Long-term use is associated with a higher risk of certain cancers, such as lymphoma and skin cancer.6. Allergic Reactions: Some individuals may experience hypersensitivity reactions, including fever and rash.Regular monitoring and consultation with a healthcare provider are essential to manage these risks effectively.

Azathioprine is primarily an immunosuppressive medication used to prevent organ rejection in transplant patients and to treat autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease. While it is not primarily classified as a cancer drug, it is a derivative of 6-mercaptopurine, which is used in certain cancer treatments. Azathioprine's role in cancer treatment is limited and not its main indication.

Azathioprine is not typically classified as a chemotherapy drug. It is an immunosuppressant medication primarily used to prevent organ rejection in transplant patients and to treat autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease.

Azathioprine is an immunosuppressive medication. It is commonly used to prevent organ rejection in transplant patients and to treat autoimmune conditions by suppressing the immune system's activity.

Azathioprine has several red flags that patients and healthcare providers should be aware of. These include:1. Bone Marrow Suppression: This can lead to leukopenia, thrombocytopenia, and anemia. Regular blood count monitoring is essential.2. Increased Risk of Infections: Due to its immunosuppressive effects, patients may be more susceptible to infections.3. Hepatotoxicity: Liver function should be monitored as azathioprine can cause liver damage.4. Gastrointestinal Disturbances: Nausea, vomiting, and diarrhea can occur.5. Hypersensitivity Reactions: These can include fever, rash, and malaise.6. Increased Risk of Malignancies: Long-term use is associated with an increased risk of certain cancers, such as lymphoma and skin cancer.Patients should report any unusual symptoms to their healthcare provider promptly. Regular monitoring and follow-up are crucial to manage these risks effectively.

While taking azathioprine, it is important to monitor blood counts, including white blood cells, red blood cells, and platelets, to detect any potential bone marrow suppression. Liver function tests should also be monitored to assess for hepatotoxicity. Additionally, monitoring for signs of infection is crucial, as azathioprine can suppress the immune system. Regular follow-up with a healthcare provider is recommended to ensure safe and effective use of the medication.

It is generally safe to drink coffee while taking azathioprine. However, it is important to monitor for any unusual symptoms or side effects. If there are any concerns or if the individual experiences any adverse reactions, it is advisable to consult with a healthcare provider.