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Cyclophosphamide may cause some mild side effects such as nausea, vomiting, loss of appetite, stomach ache, diarrhea, and darkening of the skin or nails. While nausea and vomiting can be severe, they can often be managed with dietary changes or medications. Temporary hair loss is another possibility, but hair typically regrows after treatment, sometimes with a different color or texture.

Though uncommon, some individuals may experience pain, swelling, or redness at the injection site. It's important to report these symptoms if they occur. More serious side effects require immediate medical attention, including signs of kidney or bladder issues (such as changes in urination or blood in urine), mouth sores, joint pain, and liver problems (indicated by abdominal pain, yellowing of the skin or eyes, and dark urine).

In rare cases, cyclophosphamide can affect the heart, especially at high doses or when combined with other treatments. Symptoms like chest pain, irregular heartbeat, or signs of heart failure such as unusual tiredness and swelling in the ankles should prompt urgent medical help.

This medication can reduce bone marrow function, leading to a low blood cell count. This might result in anemia, increased risk of infection, or easy bruising. Symptoms include unusual tiredness, persistent sore throat, fever, or easy bruising. Cyclophosphamide may also temporarily or permanently affect fertility in both men and women, and in some cases, increase the risk of developing other cancers long after treatment.

A severe allergic reaction to cyclophosphamide is rare but serious. Symptoms such as rash, swelling, severe dizziness, or difficulty breathing require immediate medical assistance. Always report any other unlisted effects to your healthcare provider.