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The safety information outlined here is crucial for those considering the use of Endometrin (progesterone). Pay close attention to these warnings and discuss any concerns with your healthcare provider.

• Blood Clots and Cardiovascular Risks: Endometrin (progesterone) may increase the risk of blood clots, which can lead to severe complications such as heart attacks or strokes. Inform your healthcare provider of your complete medical history, especially if you have previously experienced blood clots, as this medication may not be suitable for you.

• Depression Concerns: There is a possibility that Endometrin (progesterone) could exacerbate symptoms of depression. If you have a history of depression, promptly report any noticeable mood changes or feelings of hopelessness, fear, or despair to your healthcare provider.

• Avoidance of Other Vaginal Products: While using Endometrin (progesterone), it is advised not to use other vaginal products, including creams or medications for yeast infections. These products may interfere with the absorption of Endometrin (progesterone), reducing its effectiveness. Consult a healthcare professional to explore alternative options if needed.

In addition, certain conditions make the use of this medication inadvisable due to significant health risks. Do not use Endometrin (progesterone) if you have:

• Unexplained vaginal bleeding that hasn't been assessed by a healthcare professional.
• A known missed abortion or an ectopic pregnancy.
• Liver issues.
• A history of or current breast or genital cancer.
• A history of blood clots.
• A known allergy to progesterone products.

Ensure to consult your healthcare provider if any of these contraindications apply to you before beginning treatment with Endometrin (progesterone).

When taking this medication, some common side effects you might encounter include bloating, stomach or abdominal pain, nausea, breast tenderness, headache, drowsiness, mood swings, irritability, and vaginal discomfort. These effects are generally mild, but if they persist or worsen, consulting a healthcare provider is advisable. Additionally, some individuals report pain after egg retrieval, stomach cramps, ovarian hyperstimulation syndrome (swollen ovaries), vomiting, constipation, fatigue, vaginal irritation, burning, or discharge. While these are not uncommon, they should be monitored.

In rare cases, severe side effects may occur, requiring immediate medical attention. These include unusual vaginal bleeding, severe mood changes, swelling of the ankles or feet, yellowing of the skin or eyes, and breast lumps. More critical concerns involve blood clots, where symptoms might include persistent leg pain, sudden shortness of breath, or coughing up blood. Heart attack signs, such as chest pain or pain spreading to the shoulder, arm, neck, or jaw, and stroke symptoms like sudden difficulty speaking, walking, or severe headaches, should prompt urgent care.

Although highly unlikely, a severe allergic reaction could happen. Look out for rash, itching or swelling, especially of the face, tongue, or throat, severe dizziness, or trouble breathing. These symptoms require immediate medical help. Always remain attentive to your body's reactions and consult your healthcare provider if you notice any side effects not listed here.

When using Endometrin (progesterone), be cautious of potential interactions with other medications or supplements. It is important to inform your doctor and pharmacist about all the medications and supplements you are taking, including prescription and over-the-counter drugs, vitamins, and herbal products.

Specifically, avoid using Endometrin with Tranexamic Acid, as this combination is not recommended. Your doctor might opt for an alternative treatment. Additionally, there are several medications that are usually not recommended to be used with Endometrin but might be necessary in certain situations. If both drugs are prescribed, your doctor may adjust the dosage or frequency of one or both medications. These include, but are not limited to, Apalutamide, Aprepitant, Armodafinil, Artemether, Bexarotene, Bosentan, and others. Always consult your healthcare provider for guidance tailored to your situation.

Moreover, do not use other vaginal products during the treatment with Endometrin unless your doctor advises otherwise, as this could affect the drug's absorption.