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The medication Crinone (progesterone) carries specific safety warnings and usage instructions that are essential for patient safety. Please read the following information thoroughly and consult your healthcare provider with any concerns.

• Blood Clots: If you have a history of blood clots or conditions caused by them, such as a heart attack or stroke, inform your prescriber before starting Crinone. This medication is contraindicated for individuals with previous blood clots.

• Miscarriage Prevention: Though some fertility specialists use progesterone to prevent miscarriage, Crinone is not FDA-approved for this purpose. Discuss with your healthcare provider for appropriate options and adhere to their guidance.

• Fluid Retention: Crinone may cause fluid accumulation, particularly in the legs, ankles, and feet, due to its role in fluid regulation. This could pose risks for individuals with heart failure or kidney issues.

• Depression: Crinone has the potential to exacerbate depression due to fluctuations in progesterone levels. Notify your prescriber if you have a history of depression and monitor for mood changes or worsening symptoms like hopelessness or fear.

• Blood Sugar Levels: Progesterone can increase blood sugar levels, complicating diabetes management. Inform your prescriber if you have diabetes or prediabetes before starting treatment.

Contraindications: Do not use Crinone if you have the following conditions, as it may cause serious health complications:

• Unexplained abnormal vaginal bleeding
• Liver issues
• Breast cancer or cancer of any genital organ (e.g., ovarian, cervical)
• Missed abortion
• Blood clotting disorders

Consult your healthcare provider to discuss any of these conditions before using this medication.

When taking this medication, you may experience several common side effects. These include breast swelling or growth, drowsiness, constipation, nausea, headaches, and stomach pain. Additionally, some individuals may notice pain around the vaginal area, nervousness, a decrease in sexual desire, increased urination at night, and mild depression. It's important to remember that these effects are generally mild, but if they persist or worsen, consulting a healthcare provider is advisable.

Other side effects reported include diarrhea, vomiting, joint pain, pain during sexual activity, and vaginal discharge. While the appearance of small white gel balls in vaginal discharge is typical and harmless, any unusual discharge, itching, or odor should prompt a discussion with your healthcare provider.

Serious side effects, although rare, require immediate medical attention. These include significant mental or mood changes such as depression, nervousness, or mood swings, swelling of the hands or feet, unexplained vaginal bleeding, breast lumps, or yellowing of the skin or eyes. The medication may also increase the risk of blood clots, leading to severe complications like heart attacks or strokes. Symptoms to watch for include chest or jaw pain, sudden dizziness, shortness of breath, severe headaches, and numbness on one side of the body. Seek urgent medical help if you encounter any of these symptoms.

Allergic reactions to the medication are rare but serious. If you notice symptoms such as a rash, swelling, severe dizziness, or trouble breathing, seek medical attention right away. If you experience any side effects not listed here, reach out to your healthcare professional for guidance.