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This medication contains important safety warnings and precautions that should be carefully reviewed. Please consult your healthcare provider if you have any questions or concerns.

• Pregnancy Warning: This medication, which includes sacubitril and valsartan, poses a significant risk of causing birth defects or serious harm to an unborn baby. It is crucial to avoid using this medication during pregnancy. If you are pregnant, planning to become pregnant, or suspect you might be pregnant, immediately discuss alternative treatment options with your healthcare provider and explore reliable forms of birth control while on this medication.

• Risk of Angioedema: This medication can lead to angioedema, characterized by swelling of the face, lips, tongue, throat, or other body parts, potentially causing life-threatening breathing difficulties. Do not take this medication if you have a history of angioedema related to ACE inhibitors or ARBs. Seek emergency medical attention if you notice swelling in your face, neck, or experience stomach pain. People of African descent or those with a history of angioedema are at higher risk.

• Low Blood Pressure: This medication may cause a significant drop in blood pressure, leading to dizziness, fatigue, or lightheadedness. The risk is higher when starting the medication or increasing the dosage, particularly if you are dehydrated or have conditions causing dehydration, like diarrhea or vomiting. Stay hydrated and report any dizziness or lightheadedness to your healthcare provider. If you experience a fall or head injury, seek immediate medical care.

• Kidney Function Impairment: This medication can affect kidney function, especially in individuals with heart failure, pre-existing kidney issues, or those taking other medications that may harm the kidneys. Regular lab tests may be conducted to monitor kidney health. Inform your healthcare provider if you experience reduced urination, as this may indicate kidney problems.

• Elevated Potassium Levels: Taking this medication can lead to high potassium levels, even if your kidneys are healthy. The risk increases if you are taking other medications that raise potassium levels, such as spironolactone or eplerenone. Notify your healthcare provider if you experience symptoms like nausea, muscle weakness, or an irregular heartbeat, as untreated high potassium levels can be dangerous.

Contraindications:

• Do not use this medication if you have a history of angioedema with ACE inhibitors or ARBs.
• Avoid taking this medication within 36 hours of using an ACE inhibitor.
• If you have diabetes and are taking aliskiren, avoid using this medication concurrently.

Always consult your healthcare provider for personalized advice and guidance regarding the use of this medication, especially if you have underlying health conditions or are taking other medications.

When taking this medication, some individuals may experience common side effects such as low blood pressure, high potassium levels, cough, dizziness, and kidney problems. These effects are generally mild, but if they persist or worsen, it is advisable to consult a healthcare provider. To minimize dizziness or lightheadedness, try standing up slowly from a sitting or lying position.

There are also other side effects that have been reported, including rash, itching, and falls. If you encounter any of these, especially if they become severe, reach out to a healthcare professional for guidance.

Serious side effects, though rare, demand immediate medical attention. These include angioedema, characterized by swelling of various parts of the body such as the eyes, face, or throat. Serious kidney problems may manifest as reduced urination, swelling in the extremities, or unexplained weight gain. Elevated potassium levels can lead to symptoms like muscle weakness, chest pain, or a pounding heart. Additionally, severely low blood pressure might cause symptoms such as confusion or feeling faint. If you experience any of these severe reactions, seek urgent medical care right away.

While a very serious allergic reaction is rare, it requires immediate medical help if symptoms like a rash, severe dizziness, or trouble breathing occur. Always remain vigilant for any other side effects not mentioned here and consult a healthcare provider if necessary.