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When using this medication, it's important to be aware of potential drug interactions and other factors that may influence its effectiveness. Here are some key points to consider:

• Drug Interactions: This medication may interact with certain other drugs, potentially altering their effects. Be cautious when using it with dofetilide, epirubicin, artemether, clopidogrel, lumefantrine, metformin, moclobemide, moricizine, quinidine, and silver sulfadiazine, as these could be affected.

• Impact on Drug Clearance: This medication might slow down the elimination of other drugs from your system, potentially impacting their effectiveness. Affected medications may include fezolinetant, metoprolol, tacrine, warfarin, zaleplon, calcium channel blockers like diltiazem, tricyclic antidepressants such as amitriptyline, and theophylline.

• Absorption Changes: By reducing stomach acid, this medication can alter the absorption of certain drugs, influencing their performance. Be mindful of this if you are taking atazanavir, dasatinib, certain azole antifungals (like itraconazole, ketoconazole), levoketoconazole, pazopanib, and sparsentan. Consult with your doctor or pharmacist to understand how to manage these interactions.

• Effect of Cigarette Smoking: Smoking can impact the effectiveness of this medication. Inform your healthcare provider if you smoke or if there are changes in your smoking habits while on this medication.

• Similar Medications: This drug belongs to a class of medications known as H2 blockers, which include famotidine, nizatidine, and ranitidine. These are available both over-the-counter and by prescription. Avoid using them simultaneously with this medication to prevent any adverse effects.

It is crucial to discuss with your healthcare provider any medications you are currently taking to ensure safe and effective use of this treatment.