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You might experience headaches, dizziness, drowsiness, or diarrhea when taking this medication, but these effects are typically mild and often temporary. If they persist or worsen, it's important to consult your healthcare provider. Most people using this medication do not encounter serious side effects.

However, be vigilant for more severe symptoms such as changes in mood or mental state (like agitation, confusion, depression, or hallucinations), difficulty urinating, muscle or joint pain, or breast changes in males. High doses may lead to decreased sexual ability. Other serious signs to watch for include easy bruising or bleeding, persistent sore throat, fever, cough, breathing problems, irregular heartbeat, unusual fatigue, or signs of liver or kidney issues, such as persistent nausea, abdominal pain, dark urine, or yellowing of the skin or eyes.

Though rare, a serious allergic reaction is possible. Seek immediate medical attention if you experience a rash, severe itching or swelling (especially of the face, tongue, or throat), intense dizziness, or trouble breathing. Remember, this list does not include all potential side effects. If you notice other unusual symptoms, reach out to your healthcare provider.

Certain medications can interact with this drug. These include dofetilide, epirubicin, ticlopidine, artemether, clopidogrel, lumefantrine, metformin, moclobemide, moricizine, quinidine, and silver sulfadiazine. This medication may slow down how your body removes other drugs, potentially affecting their effectiveness. Some of these drugs are fezolinetant, metoprolol, tacrine, warfarin, zaleplon, calcium channel blockers (like diltiazem), tricyclic antidepressants (such as amitriptyline), and theophylline. Additionally, because this drug reduces stomach acid, it can alter the absorption and effectiveness of certain medicines, such as atazanavir, dasatinib, specific azole antifungals (like itraconazole, ketoconazole), levoketoconazole, pazopanib, and sparsentan. Consult your doctor or pharmacist to see if your medications are affected and how to manage these interactions.

Smoking can influence how this medication works. Inform your doctor if you smoke or if you change your smoking habits while on this medication. This medicine, along with other H2 blockers like famotidine, nizatidine, and ranitidine, can be bought with or without a prescription. Avoid taking them simultaneously.