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Nonsteroidal anti-inflammatory drugs, such as diclofenac, are associated with certain risks and precautions that should be carefully considered. Below is essential safety and warning information:

• Diclofenac may rarely increase the risk of heart attack or stroke, potentially occurring at any time during use, especially with prolonged use. The risk is heightened in older adults or individuals with heart disease or increased risk factors such as smoking, family history of heart disease, high blood pressure, or diabetes.
• Avoid using diclofenac immediately before or after coronary artery bypass graft (CABG) surgery.
• The drug can occasionally lead to serious, sometimes fatal, bleeding in the stomach or intestines. This may happen without warning and at any time during the treatment. The risk is greater in older patients.
• Discontinue use and seek immediate medical attention if you experience any of these serious side effects: persistent stomach or abdominal pain, black or bloody stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, sudden vision changes, or difficulty speaking.
• Discuss the potential benefits and risks of diclofenac with your healthcare provider or pharmacist to ensure it is safe and appropriate for your condition.

When using this medication, you might experience mild skin irritation or redness at the application site. This is usually harmless, but if it persists or worsens, it is advised to consult a healthcare professional. While most people using this medication do not experience severe side effects, it's important to monitor your blood pressure regularly, as the drug may cause an increase. Inform your healthcare provider if your blood pressure readings are consistently high.

In rare cases, serious side effects can occur. These include signs of kidney problems such as changes in urine output, or symptoms of heart failure like swollen ankles or feet, fatigue, or sudden weight gain. Promptly seek medical attention if you notice any of these symptoms. Additionally, this medication may rarely lead to serious liver disease. Symptoms to watch for include persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the eyes or skin, and dark urine. Immediate medical assistance is crucial if these symptoms appear.

Although a severe allergic reaction is unlikely, it is important to be aware of its signs, which include fever, swollen lymph nodes, rash, itching, swelling of the face, tongue or throat, severe dizziness, and difficulty breathing. Should any of these occur, urgent medical attention is necessary. Please note that this list does not cover all possible side effects. If you experience any effects not mentioned, consult your healthcare provider for advice.