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Baricitinib, marketed as Olumiant, carries important safety considerations that should be reviewed before and during treatment. Understanding these risks and taking appropriate precautions can help manage potential side effects effectively. Below are the key safety warnings and precautions:

• Risk of Serious Infections: Baricitinib can impair your immune system's ability to combat infections, increasing the risk of serious bacterial, viral, or fungal infections, such as pneumonia, tuberculosis (TB), and shingles. Inform your healthcare provider immediately if you experience symptoms like fever, chills, persistent cough, body aches, or painful urination. Patients should undergo TB testing before and during treatment, especially if they have been in contact with TB or traveled to areas with high fungal infection rates.

• Increased Risk of Death: While not observed specifically with Baricitinib, other JAK inhibitors have been linked to a higher risk of death in older adults with heart-related risk factors. Discuss the risks and benefits with your healthcare provider if you are age 50 or older or have conditions like high blood pressure, cholesterol, or blood sugar.

• Potential Cancer Risk: There is a possibility of developing cancers such as lymphoma or skin cancer during treatment with JAK inhibitors, including Baricitinib. Regular monitoring by your healthcare provider is recommended. Protect your skin from sun exposure and avoid tanning beds to minimize the risk of skin cancer.

• Blood Clots: Baricitinib may increase the risk of blood clots, including heart attacks and strokes, particularly in those with cardiovascular risk factors or a history of smoking. Seek immediate medical attention if you experience symptoms like shortness of breath, chest pain, sudden dizziness, or unusual swelling.

• Allergic Reactions: Severe allergic reactions are rare but possible. If you develop symptoms like facial swelling, difficulty breathing, or rashes, seek emergency medical assistance.

• Gastrointestinal Tears: Some patients have reported tears in the gut during clinical trials. Prompt medical attention should be sought if you experience severe stomach pain or notice blood in your stool.

• Changes in Blood Cell Counts: Baricitinib can lead to changes in red and white blood cell counts, increasing the risk of anemia and infections. Regular blood tests are recommended to monitor cell counts. Inform your provider if you experience fatigue, paleness, rapid heartbeat, or frequent infections.

Baricitinib requires careful consideration and monitoring due to these potential risks. Always discuss any concerns or symptoms with your healthcare provider to ensure safe and effective use of the medication.

When taking this medication, some individuals may experience side effects. Commonly reported mild side effects include upper respiratory infections, which occur in up to 16% of users. These typically do not cause much concern, but if they persist or become troublesome, it is advisable to consult a healthcare professional.

More serious side effects include raised liver enzymes, affecting 9-18% of users, and infections, occurring in up to 9%. In some cases, individuals may develop a headache, acne, high cholesterol, or a urinary tract infection, with frequencies ranging between 4-7%. While these side effects can be uncomfortable, they usually do not pose a serious risk. However, monitoring by a healthcare provider is recommended to manage and mitigate them.

Rare but severe side effects require immediate medical attention. These include signs of anemia, such as unusual tiredness or pale skin, symptoms of liver disease like persistent nausea or yellowing of the skin and eyes, and indicators of a serious stomach or intestinal tear, such as severe abdominal pain. Additionally, although a very serious allergic reaction is rare, it is crucial to seek urgent medical help if you notice symptoms like rash, swelling, or difficulty breathing. Always remain vigilant and report any unexpected symptoms to your healthcare provider.