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Baricitinib, marketed as Olumiant, carries important safety considerations that should be reviewed before and during treatment. Understanding these risks and taking appropriate precautions can help manage potential side effects effectively. Below are the key safety warnings and precautions:

• Risk of Serious Infections: Baricitinib can impair your immune system's ability to combat infections, increasing the risk of serious bacterial, viral, or fungal infections, such as pneumonia, tuberculosis (TB), and shingles. Inform your healthcare provider immediately if you experience symptoms like fever, chills, persistent cough, body aches, or painful urination. Patients should undergo TB testing before and during treatment, especially if they have been in contact with TB or traveled to areas with high fungal infection rates.

• Increased Risk of Death: While not observed specifically with Baricitinib, other JAK inhibitors have been linked to a higher risk of death in older adults with heart-related risk factors. Discuss the risks and benefits with your healthcare provider if you are age 50 or older or have conditions like high blood pressure, cholesterol, or blood sugar.

• Potential Cancer Risk: There is a possibility of developing cancers such as lymphoma or skin cancer during treatment with JAK inhibitors, including Baricitinib. Regular monitoring by your healthcare provider is recommended. Protect your skin from sun exposure and avoid tanning beds to minimize the risk of skin cancer.

• Blood Clots: Baricitinib may increase the risk of blood clots, including heart attacks and strokes, particularly in those with cardiovascular risk factors or a history of smoking. Seek immediate medical attention if you experience symptoms like shortness of breath, chest pain, sudden dizziness, or unusual swelling.

• Allergic Reactions: Severe allergic reactions are rare but possible. If you develop symptoms like facial swelling, difficulty breathing, or rashes, seek emergency medical assistance.

• Gastrointestinal Tears: Some patients have reported tears in the gut during clinical trials. Prompt medical attention should be sought if you experience severe stomach pain or notice blood in your stool.

• Changes in Blood Cell Counts: Baricitinib can lead to changes in red and white blood cell counts, increasing the risk of anemia and infections. Regular blood tests are recommended to monitor cell counts. Inform your provider if you experience fatigue, paleness, rapid heartbeat, or frequent infections.

Baricitinib requires careful consideration and monitoring due to these potential risks. Always discuss any concerns or symptoms with your healthcare provider to ensure safe and effective use of the medication.

When taking Olumiant (baricitinib), it's important to be aware of potential interactions with other medications, as these can affect how Olumiant works or increase the risk of side effects. Here are some key interactions to consider:

Strong OAT3 Inhibitors: Medications like Probenecid, used to treat gout, can increase the levels of Olumiant in your body. If you're prescribed both, your doctor may reduce your Olumiant dose to minimize side effects.

Other JAK Inhibitors and Biologic DMARDs: Combining Olumiant with other Janus kinase (JAK) inhibitors or biologic disease-modifying antirheumatic drugs (DMARDs) hasn't been studied extensively. Using these together may increase the risk of infections. Your doctor will assess whether this combination is appropriate for you.

Immunosuppressants: Drugs that suppress the immune system, such as Azathioprine or Cyclosporine, may heighten the risk of infections when taken with Olumiant. Your healthcare provider will carefully consider the benefits and risks before recommending this combination.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Common pain relievers like Ibuprofen or Naproxen can increase the risk of gastrointestinal issues, including perforations, when used with Olumiant. It's important to discuss the use of NSAIDs with your doctor if you're on Olumiant.

Corticosteroids: Medications such as Prednisone, used to reduce inflammation, may also raise the risk of infections and gastrointestinal problems when combined with Olumiant. Your doctor will monitor you closely if both are prescribed.

Methotrexate: Often used to treat rheumatoid arthritis, methotrexate can increase the risk of infections and gastrointestinal perforations when taken with Olumiant. Your healthcare provider will evaluate whether this combination is suitable for you.

Alcohol: While no direct interaction between Olumiant and alcohol is known, both can cause side effects like nausea and headache. Drinking alcohol during Olumiant treatment may intensify these effects. Additionally, both can impact liver function, so it's advisable to limit alcohol consumption and consult your doctor about safe levels.

Vaccines: Live vaccines, such as those for measles, mumps, rubella (MMR), and the nasal flu vaccine, should be avoided during Olumiant treatment due to an increased risk of infection. Ensure your vaccinations are up to date before starting Olumiant, and discuss any necessary vaccines with your doctor.

Always inform your healthcare provider about all medications, supplements, and over-the-counter drugs you're taking before starting Olumiant. This will help prevent potential interactions and ensure your treatment plan is safe and effective.