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This medication is generally well-tolerated, with side effects being rare. Some individuals may experience harmless darkening of stools or the tongue, which typically resolves once the medication is discontinued. While severe side effects are uncommon, persistent vomiting or diarrhea can lead to dehydration. It's important to be alert for signs of dehydration, such as reduced urination, dry mouth, excessive thirst, a rapid heartbeat, or dizziness, and seek medical attention if they occur.

Serious side effects, though rare, should be addressed immediately. These include ringing in the ears, hearing loss, and signs of bleeding in the stomach or intestines, such as persistent abdominal pain, vomit resembling coffee grounds, or black, tarry stools. If you encounter any of these symptoms, discontinue the medication and consult a healthcare professional right away.

A very serious allergic reaction is also rare but requires urgent medical attention. Symptoms may include rash, itching or swelling, especially of the face, tongue, or throat, severe dizziness, or difficulty breathing. Always contact a healthcare provider if you notice any other side effects not mentioned here. Your safety is important, and prompt communication with a healthcare professional ensures the best care.

This medication can interact with several other drugs, including valproic acid, carbonic anhydrase inhibitors like acetazolamide, corticosteroids such as prednisone, dichlorphenamide, and methotrexate. It may also increase the risk of bleeding if taken with other medications that have a similar effect, such as anti-platelet drugs like clopidogrel and blood thinners like dabigatran, enoxaparin, or warfarin.

Be sure to review both prescription and over-the-counter medication labels, as many contain pain relievers or fever reducers (NSAIDs like aspirin, ibuprofen, or naproxen) similar to this drug, which could heighten side effects. If your healthcare provider has advised you to take low-dose aspirin (typically 81-162 milligrams daily) to prevent heart attack or stroke, continue doing so unless instructed otherwise by your doctor. Consult your doctor or pharmacist for more information.

Additionally, this medication might affect certain medical or lab tests, such as intestinal x-rays using contrast dye, potentially leading to false results. Ensure all healthcare providers and lab technicians are aware that you are using this medication.