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The following safety information highlights important considerations for those using Dupixent (dupilumab). Please read carefully and consult your healthcare provider if you have any questions or concerns.

• Severe Allergic Reactions: Dupixent may cause life-threatening allergic reactions. Be attentive to symptoms such as rash, difficulty breathing, facial swelling, itching, redness, dizziness, and joint pain. Seek immediate medical assistance if these occur.

• Eye Inflammation: Users of Dupixent may experience eye inflammation. Symptoms include blurred vision, pink eye, itching, increased tearing, eye pain, or light sensitivity. Inform your healthcare provider if you notice these signs. They may prescribe medication or recommend an eye examination.

• Vascular Inflammation: Dupixent can lead to an increase in white blood cells, particularly eosinophils, which may cause inflammation of blood vessels. This risk is higher in individuals using Dupixent for asthma or those who have recently discontinued oral steroids. Report symptoms such as rash, chest pain, shortness of breath, tingling, numbness, or fever to your provider.

• Asthma Management: Dupixent is not suitable for treating asthma attacks or severe episodes. Instead, use a rescue inhaler like albuterol (ProAir). If your symptoms persist or worsen, seek medical help promptly.

• Joint Pain: Some individuals using Dupixent may experience severe joint pain, which can occur any time from one day to several months after starting treatment. If you experience joint discomfort, contact your healthcare provider.

• Serious Parasitic Infections: Dupixent may impair your ability to fight infections, increasing the risk of serious parasitic infections, particularly in children. Do not use Dupixent if you or your child has an active or recurrent infection. Notify your provider if symptoms such as fever, restlessness, weight loss, or itching occur.

• Vaccine Interactions: The impact of Dupixent on vaccines is not fully understood. It may interfere with vaccine efficacy and increase the risk of infection from live vaccines. Avoid live vaccines, such as MMR, while using Dupixent. Discuss your or your child's vaccination history with your healthcare provider to ensure all vaccines are current.

In case of any adverse reactions or symptoms, it is crucial to contact your healthcare provider immediately. This information is intended to help you use Dupixent safely and effectively.

When using this medication, some common side effects you might experience include redness, irritation, or pain at the injection site, and occasional swelling or itching of the eyes or eyelids. These effects are generally mild, but if they persist or worsen, it's advisable to consult your healthcare provider. Additionally, eye redness and cold sores are also reported by some users.

There are other side effects that may occur, such as eyelid and corneal inflammation, itchy or dry eyes, and viral infections like genital herpes. Some individuals also report sore throat, joint and muscle pain, and upper respiratory tract infections, which can lead to symptoms like trouble breathing, cough, or fever. Dizziness may also be experienced.

Serious side effects, although rare, require immediate medical attention. These include severe allergic reactions characterized by difficulty breathing, rash, fever, swelling of the face, lips, or tongue, a fast heartbeat, nausea, and vomiting. If you encounter any of these serious symptoms, seek urgent medical care. Always be vigilant about new or worsening symptoms and discuss them with your healthcare provider.