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Here is important safety information about the use of Flovent (fluticasone). Please review these details and consult your healthcare provider if you have any questions or concerns.

• Fungal Infections: Flovent (fluticasone) can cause oral thrush, a fungal infection in the mouth and throat. To reduce this risk, rinse your mouth with water and spit after each use. Symptoms include white patches, a cotton-like feeling, pain while eating or swallowing, and loss of taste. Contact your healthcare provider if you notice these symptoms, as antifungal treatment may be necessary.

• Bronchospasm: Inhaled medications like Flovent (fluticasone) may cause bronchospasm, leading to breathing difficulties, wheezing, coughing, and chest discomfort. If you experience shortness of breath after using Flovent, use your rescue inhaler immediately and seek medical attention.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, are possible. Symptoms may include hives, rash, facial swelling, and difficulty breathing. Obtain medical help immediately if these occur.

• Altered Stress Hormone Levels: Long-term or excessive use of Flovent (fluticasone) can affect cortisol levels, leading to symptoms like weight gain, facial puffiness, muscle weakness, fatigue, nausea, and vomiting. Use only as directed, avoiding more than the prescribed dose, and opt for the lowest effective dose for the shortest duration.

• Growth in Children: Flovent (fluticasone) can potentially delay growth in children. Although growth rates generally normalize after stopping the medication, the long-term effects are not fully understood. Use the lowest necessary dose for the shortest time and consult with your child's healthcare provider if you have concerns.

• Eye and Vision Problems: Long-term use of Flovent may increase the risk of eye issues such as high intraocular pressure, glaucoma, and cataracts. Consult an eye specialist if you have a history of these conditions or if you notice vision changes while using this medication.

• Contraindication: Do not use Flovent (fluticasone) for treating sudden asthma attacks, as it may not provide the immediate relief needed.

It is essential to follow these guidelines to use Flovent (fluticasone) safely. Always discuss any concerns with your healthcare provider.

When using Flovent HFA, it's important to be aware of potential interactions with other substances:

Medications: Flovent HFA contains fluticasone propionate, which is processed in the body by an enzyme called CYP3A4. Certain medications can inhibit this enzyme, leading to increased levels of fluticasone in the body and a higher risk of side effects. Notable strong CYP3A4 inhibitors include:

• Ritonavir
• Atazanavir
• Clarithromycin
• Indinavir
• Itraconazole
• Nefazodone
• Nelfinavir
• Saquinavir
• Ketoconazole
• Telithromycin

Combining Flovent HFA with these medications is generally not recommended due to the potential for increased systemic corticosteroid effects. For instance, using fluticasone with ritonavir has been associated with conditions like Cushing's syndrome and adrenal suppression. Similarly, coadministration with ketoconazole has led to increased fluticasone levels and reduced cortisol levels.

Food and Beverages: While specific food interactions with Flovent HFA are not well-documented, it's advisable to consult your healthcare provider regarding any dietary considerations.

Other Medical Conditions: Certain health conditions may influence how Flovent HFA works or increase the risk of side effects. Inform your doctor if you have:

• Liver disease
• Osteoporosis
• Eye conditions like glaucoma or cataracts
• Any active infections

Always discuss your full medical history and current medication list with your healthcare provider to ensure Flovent HFA is safe and effective for you.