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This information outlines critical safety considerations for the use of Nucala (mepolizumab). It is important to read and understand these warnings, and consult your healthcare provider if you have any questions or concerns.

• Allergic Reactions: Nucala (mepolizumab) has the potential to cause severe allergic reactions, such as hives, wheezing, breathing difficulties, or swelling of the face, mouth, tongue, or throat (anaphylaxis). These reactions may occur within hours or even days after administration. Therefore, initial treatments should be conducted under medical supervision, with close monitoring following each dose to ensure no serious reactions occur. If you experience any symptoms of an allergic reaction outside a healthcare facility, seek emergency medical help immediately by calling 911.

• Not for Acute Asthma Attacks: Nucala (mepolizumab) is designed to be an adjunctive maintenance therapy for asthma, meant to be used alongside other asthma medications for long-term management. It is not suitable for treating acute asthma attacks; for immediate relief during an asthma attack, use a rescue inhaler such as albuterol.

• Corticosteroid Use: If you are on oral or inhaled corticosteroids, do not abruptly discontinue them without consulting your healthcare provider, even if you notice improvements with Nucala (mepolizumab). Stopping corticosteroids suddenly can lead to withdrawal symptoms such as dizziness, extreme fatigue, body aches, and vomiting. Your healthcare provider will guide you on how to safely reduce or discontinue corticosteroid use if necessary.

• Infection Risk: There is a rare risk of developing herpes zoster (shingles) while on Nucala (mepolizumab). Discuss with your healthcare provider whether you should receive the herpes zoster vaccine (Shingrix) before starting this medication.

When using this medication, there are a few common side effects that may occur. These include headaches and reactions at the injection site, such as pain, redness, swelling, itching, or burning. These are generally mild and affect a small percentage of users. Fatigue and back pain are also reported but are usually manageable. If these effects persist or worsen, consulting a healthcare provider is advisable to ensure your comfort and safety.

In addition to the common side effects, some individuals may experience throat or joint pain. While these are less common, they should be monitored. If the symptoms become bothersome or more severe, it's important to contact a healthcare provider for guidance.

Although serious side effects are rare, it is crucial to be aware of them. A severe allergic reaction, identified by symptoms such as a rash, swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing, requires immediate medical attention. Muscle aches, pain, or spasms should also be promptly reported to a healthcare professional. Remember, while these severe reactions are unlikely, being informed helps you respond effectively should they occur.