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When using Follistim AQ (follitropin beta), it's crucial to be aware of important safety considerations and potential risks. If you have any concerns, please consult your healthcare provider. Here are key warnings associated with this medication:

• Swollen Ovaries: Follistim AQ may cause the ovaries to enlarge, especially with high doses or prolonged use. Regular ultrasound monitoring by your healthcare provider is essential. If significant swelling is detected, discontinuation of the medication and avoiding sexual activity may be advised. Report any pelvic or lower abdominal pain immediately to your provider.

• Ovarian Hyperstimulation Syndrome (OHSS): This condition can occur post-treatment, leading to enlarged ovaries, pain, nausea, vomiting, or diarrhea. It can escalate to more severe symptoms such as breathing difficulties and ovarian rupture. These symptoms often resolve with the onset of menstruation but require immediate medical attention if they occur within 7-10 days after treatment, especially if pregnancy is achieved.

• Lung Problems and Blood Clots: The use of Follistim AQ may increase the risk of serious lung issues and blood clots, which can lead to heart attacks, strokes, or pulmonary embolism. This risk is heightened by smoking, a personal or family history of blood clots, or OHSS. Immediate medical attention is necessary for symptoms like leg or arm pain, chest pain, severe headaches, breathing difficulties, or sudden changes in speech or vision.

• Ovarian Twisting: There is a risk of ovarian torsion, which can cut off blood flow to the ovary, particularly in those with polycystic ovarian syndrome (PCOS), a history of abdominal surgery, or OHSS. Disclose any history of ovarian cysts or surgeries to your provider before starting treatment.

• Multiple Pregnancies: Gonadotropin treatments like Follistim AQ significantly increase the likelihood of conceiving multiples (e.g., twins, triplets). Discuss the implications with your partner prior to initiating treatment.

• Pregnancy Complications: There is an increased risk of birth defects, miscarriages, and ectopic pregnancies when using gonadotropin fertility treatments. The exact cause is unclear, and your healthcare provider may wish to monitor your pregnancy more closely.

Please ensure to discuss your medical history thoroughly with your healthcare provider before beginning treatment with Follistim AQ.

When taking this medication, some people may experience mild side effects such as headaches, stomach pain, bloating, acne, or pain and redness at the injection site. These effects are common and usually manageable. However, if they persist or worsen, it is advisable to consult a healthcare provider.

Occasionally, individuals might also experience pelvic pain or discomfort, ovarian cysts, breast tenderness or growth in men, fatigue, or nausea. While these are not uncommon, it is important to monitor them and seek advice if they become bothersome.

There are rare but serious side effects that require immediate medical attention. These include flu-like symptoms, unusual vaginal bleeding, swelling of the ankles, hands, or feet, and symptoms indicative of a heart attack or stroke such as chest pain, difficulty breathing, sudden dizziness, or vision changes. Additionally, ovarian hyperstimulation syndrome (OHSS) is a potential risk, characterized by severe pelvic pain, rapid weight gain, nausea, and reduced urination.

Severe allergic reactions, though rare, may present with rash, swelling, or trouble breathing. In such cases, urgent medical help is necessary. Additionally, watch for other severe symptoms like unexpected pelvic pain or unusual bleeding, which could indicate an ectopic pregnancy. Always stay vigilant and consult a healthcare provider if you notice any concerning symptoms.