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The following information outlines important safety warnings and potential risks associated with the use of triamcinolone injection (Kenalog). It is crucial to read these carefully and discuss any concerns with your healthcare provider.

• Serious Nervous System Risks: Administration of triamcinolone via epidural (spinal) injections has been linked to significant nervous system issues, including spinal cord damage, paralysis, blindness, and stroke. Consequently, triamcinolone should not be injected into the spine.

• Severe Allergic Reactions: Triamcinolone can trigger serious allergic responses. If you encounter breathing difficulties, facial or throat swelling, dizziness, or severe rash after receiving the injection, seek emergency medical assistance immediately.

• Heart and Kidney Concerns: High doses of triamcinolone may increase blood pressure, cause fluid retention, and result in potassium loss. Individuals with a history of high blood pressure, heart failure, or kidney issues should be closely monitored for swelling, weight gain, and electrolyte imbalances. Reducing salt intake and taking potassium supplements might be necessary.

• Hormonal Effects: Long-term use of triamcinolone can lead to adrenal insufficiency, where the adrenal glands no longer produce hormones naturally. Sudden discontinuation can cause steroid withdrawal symptoms such as fatigue, joint or muscle pain, and low energy. Hormone imbalance could persist for months after stopping the medication.

• Increased Infection Risk: Triamcinolone weakens the immune system, increasing susceptibility to new infections and exacerbating existing ones. At higher doses, infections can become severe or life-threatening. Monitoring for signs of infection and dose adjustments may be required.

• Eye Health Issues: Prolonged use of triamcinolone (beyond six weeks) may increase eye pressure in some individuals. Regular monitoring of eye pressure is advised for those with a history of eye problems.

• Gastrointestinal Risks: Triamcinolone can elevate the risk of gastrointestinal perforation, especially in individuals with peptic ulcers, diverticulitis, ulcerative colitis, or recent intestinal surgery. Report severe stomach pain, nausea, vomiting, fever, or poor appetite to your healthcare team.

• Bone Weakness: The medication can weaken bones and increase osteoporosis risk, particularly in children and post-menopausal women. Regular bone monitoring may be necessary depending on the frequency of use.

• Mood and Behavior Changes: Mood swings, sleep disturbances, personality changes, and depression may occur. Those with a history of mental health issues should inform their prescriber, as triamcinolone can exacerbate these conditions.

• Cancer Risk: Though rare, long-term use of corticosteroids like triamcinolone has been linked to Kaposi's sarcoma. Report any unusual skin changes or swelling to your prescriber promptly.

Contraindications: Triamcinolone should not be used in individuals with idiopathic thrombocytopenic purpura (ITP), a condition that reduces platelets, especially when the injection is administered into the muscle. Always consult your healthcare provider if any of these conditions apply to you.

When using this medication, some people may experience mild effects such as burning, itching, irritation, or dryness at the application site. These usually subside as your body adjusts. If they persist or worsen, it's important to consult a healthcare professional. Other common side effects can include swelling, high blood pressure, high blood sugar, muscle weakness, stomach pain, trouble sleeping, mood changes, headache, acne, and weight gain.

More serious side effects are less common but should not be ignored. These include stretch marks, skin thinning or discoloration, greatly increased hair growth, small red bumps on the skin (folliculitis), and possible worsening of skin infections. It is crucial to seek immediate medical attention if you experience symptoms of severe allergic reactions like rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing.

Additionally, although rare, the medication may be absorbed into the bloodstream, potentially causing unusual fatigue, weight loss, headache, swelling in ankles or feet, increased thirst or urination, and vision problems. Children, in particular, may show slowed growth. If these occur, prompt medical consultation is advised. Keep in mind that this is not a complete list of side effects, and any other unexpected symptoms should also be reported to a healthcare provider.